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Chagas disease is one of the most important neglected diseases with an estimated number of 12 million infected individuals, the majority living in Central and South America. The Trypanosoma cruzi (T.cruzi) protozoan parasite is the etiological agent of Chagas disease. T.cruzi is highly genetically d...
ORGANISM(S): Trypanosoma cruzi 
2018-03-19 | PXD008088 | Pride
Proposal of an S-Trap-based proteomics workflow for amyloid typing of EMBs coupled with a scoring algorithm based on protein intensities.The protocol and the algorithm have been validated by the comparison of MS-based diagnosis with immunohistochemistry diagnosis and patient clinical data. The study...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD082501 | Pride
Amyloidosis typing is crucial to determine the best therapeutic strategy for patients. Since conventional histological techniques often fail, the identification of amyloid precursors by mass spectrometry became the new standard. However, without quantification, selecting the amyloid precursor from p...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD039814 | Pride
Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. However, it may not be suitable for early-stage renal amyloidosis with minor damages. Here, we aimed to develop parallel reaction monitoring (PRM)-based targeted proteomics to ach...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038265 | Pride
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