Tyrosine phosphatase substrates

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CHEBI:16709 (1)
CHEBI:26271 (1)
CHEBI:17126 (1)
CHEBI:22660 (1)
CHEBI:27570 (1)

Metabolite Name

Uridine monophosphate (1)
Cystenylglycine (1)
Hydroxycinnamicacid (1)
N-acetyl-serine (1)
Guanosine monophosphate (1)
Cytidine monophosphate (1)
5-benzoyloxypentyl glucosinolate (1)
4-benzoyloxybutyl glucosinolate (1)
3-benzoyloxypropyl glucosinolate (1)
Glucoibarin (1)
Glucoalyssin (1)
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S-Adenosyl-Methionine (1)
Glucobrassicin (1)
Glucoraphanin (1)
Gluconasturtiin (1)
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Carbamoylphosphate (1)
Glucolesquerellin (1)
8-Methylthiooctyl glucosinolate (1)
7-Methylthioheptyl glucosinolate (1)
Aconitate (1)
Argininosuccinate (1)
Glycerylphosphorylcholine (1)
N-Acetylaspartate (1)
Glyceraldehyde 3-phosphate (1)
Phosphorylethanolamine (1)
Oleylcarnitine (1)
Pyrophosphoric acid (1)

IsPrivate

False (1)

Modelling Approach

Differential equation model (1)

Study type

Transcription profiling by array (297)
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Release Date

2010 (76)
2013 (67)
2012 (59)
2011 (49)
2014 (45)
2015 (39)
2016 (36)
2009 (31)
2008 (25)
2007 (17)
2006 (15)
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2000 (1)

Lab affiliation

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany (3)
Lineberger Comprehensive Cancer Center at UNC Chapel Hill (3)
Lanzhou Veterinary Research Institute (2)
The University of Sydney (2)
1. Institut de Recherche en Immunologie et Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada. 2. Département de Biochimie et Biologie Moléculaire, Université de Montréal, Montréal, Québec, Canada. 3. Département de Chimie, Université de Montréal, Montréal, Québec, Canada (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Associate Professor Director of Graduate Studies BMBB Biochemistry, Molecular Biology, and Biophysics 7-140 MCB 420 Washington Avenue SE Minneapolis, MN 55455 (1)
Breast Cancer Clinical Research Unit Centro Nacional de Investigaciones Oncológicas – CNIO Madrid, Spain. (1)
Caltech Proteome Exploration Laboratory (1)
Cambridge Institute for Medical Research (1)
Carnegie Institution for Science (1)
Cell Biology Department, Harvard Medical School (1)
Center for Molecular Medicine University Medical Center Utrecht Utrecht 3584CG The Netherlands (1)
Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore 575018, India (1)
Chair of Proteomics and Bioanalytics Technische Universitaet Muenchen Partner Site of the German Cancer Consortium Emil Erlenmeyer Forum 5 85354 Freising Germany (1)
Deaprtment of Biological Sciences - Universtiy of Alberta (1)
Department of Biochemistry, College of Medicine, University of Saskatchewan (1)
Department of Biochemistry, Department of Chemistry, Purdue University, West Lafayette, IN 47906 (1)
Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA (1)
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA (1)
Department of Microbiology; Icahn School of Medicine at Mount Sinai; New York, NY, 10029; USA (1)
Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG), 9713 AV Groningen, The Netherlands (1)
Department of Respiratory Medicine and Allergology, Faculty of Medicine, Lund University, Sweden (1)
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium (1)
Departments of Genetics and Biochemistry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA (1)
Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy (1)
Epithelial Systems Biology Laboratory Systems Biology Center Division of Intramural Research National Heart, Lung and Blood Institute National Institutes of Health (1)
Evotec (München) GmbH, Martinsried, Germany (1)
Executive Director Cancer Research, Peter MacCallum Cancer Centre. Head, The Sir Peter MacCallum Department of Oncology, The University of Melbourne. (1)

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Systematic Identification of SHP2 Phosphatase Substrates

Phosphatases play essential roles in normal cell physiology and diseases like cancer. The challenges of studying phosphatases have limited our understanding of their substrates, molecular mechanisms, and unique functions within highly complicate networks. Here we introduce a novel strategy using sub...

ORGANISM(S): Homo sapiens (Human)

2022-09-20 | PXD028404 | Pride

The Arabidopsis tyrosine phosphatase RLPH2 targets D-group MAP kinases

Knowing that biochemically RLPH2 is a tyrosine phosphatase, we selectively In an attempt to discover RLPH2 substrates we decided to use the power of phospho-proteomics. Immunoprecipitated tyrosine phosphorylated peptides from enriched phospho-peptide pools derived from these plant extracts. Mass spe...

ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress)

2026-01-26 | PXD038689 | Pride

Phosphoproteomics Arabidopsis Protein phosphatase Mapk

Vascular endothelial protein tyrosine phosphatase: Identification of novel cell junction-related substrates and a ternary receptor complex with EPHB4 and TIE2

Vascular endothelial protein tyrosine phosphatase (VE-PTP, PTPRB) is a receptor type phosphatase that is crucial for the regulation of endothelial junctions and blood vessel development. VE-PTP regulates vascular integrity by dephosphorylating substrates which are key players in endothelial junction...

ORGANISM(S): Mus musculus (Mouse)

2019-08-20 | PXD011940 | Pride

Lc-msms Mouse Tyrosine phosphatase Endothelial cells Substrate trapping

Novel Brutons Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays

BTK substrate profile determined by treating digest KG-1 cell lysate with alkaline phosphatase followed by recombinant BTK. Samples were enriched with PolyMac phosphoenrichment kits prior to analysis. We have organized our uploaded files into three main folders: 1. BTK KALIP MS raw files: raw mass ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2021-11-22 | MSV000088429 | MassIVE

Proteomic profiling by array of tyrosine kinase activity in metastatic malignant melanoma from human tissue specimens

Tyrosine kinase activity profiling of metatstatic malignant melanoma and normal skin tissue samples was performed using peptide kinase arrays. All samples were run in triplicates with and withouth inhbitor PLX4032 and Sutent Malate in order to identify how tyrosine kinases responds to kinase inhibit...

ORGANISM(S): Homo sapiens

2013-01-17 | E-MTAB-1245 | biostudies-arrayexpress

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...

2025-05-29 | MTBLS3707 | MetaboLights

Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence.

Not available

S-EPMC3039405 | biostudies-literature

Tyrosine 601 of Bacillus subtilis DnaK undergoes phosphorylation and is crucial for chaperone activity and heat shock survival

In order to screen for cellular substrates of the Bacillus subtilis BY-kinase PtkA, and its cognate phosphotyrosine-protein phosphatase PtpZ, we performed a triple SILAC-based quantitative phosphoproteome analysis. Detected tyrosine phosphorylation sites for which the phosphorylation level decreased...

ORGANISM(S): Bacillus subtilis

2016-05-09 | PXD003764 | Pride

Molecular chaperons Silac Protein phosphorylation Quantitative phosphoproteomics Bacterial protein-tyrosine kinases Protein folding

Quantitative Proteomics Identifies Protein Tyrosine Phosphatase 1B as Modulator of B Cell Antigen Receptor Signaling

B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...