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ProteomicsComparison non-targeting hRNA hESCs versus UBE2K shRNA hESCs
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018625 | Pride
Histones Ubiquitin proteasome system Hescs 
UnknownMicroglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU.
Not available
S-EPMC11234284 | biostudies-literature
ProteomicsIdentification of UBE2K-dependent polyubiquitin linkages on PCNA
A label-free quantitative mass spectrometry analysis was performed to identify UBE2K-dependent polyubiquitin linkages on PCNA.
ORGANISM(S): Homo sapiens (Human) 
2026-10-18 | PXD080900 | Pride
Pcna Polyubiquitin linkage Lc-ms Ube2k 
GenomicsRegulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [RNA-Seq]
Regulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [RNA-Seq]
PRJNA611705 | ENA
GenomicsRegulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [ChIP-Seq]
Regulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [ChIP-Seq]
PRJNA611708 | ENA
ProteomicsThe UBA-domain of Ubc1/Ube2K Facilitates the Assembly of K48-/K63-Branched Ubiquitin Chains
Assembly of polymeric ubiquitin (Ub) chains is an essential posttranslational protein modification that regulates widespread intracellular processes in eukaryotic cells. Factors and mechanisms that regulate the formation of Ub chains are key to the understanding of many cellular processes. The E2 en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD018651 | Pride
Ubc1/ube2k ubiquitin k48-/k63-branched ubiquitin prm 
UnknownThe molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.
Not available
S-EPMC4655369 | biostudies-literature
UnknownStructure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Not available
S-EPMC8964413 | biostudies-literature
GenomicsRegulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [ChIP-Seq]
We find that loss of UBE2K leads to accumulation of histone leading to increase in overall load for epigenetic marks and thus hindering differentiation.Our results provide a novel link between ubiquitination, histone regulation and hESC differentiation into neurons. To test whether UBE2K knockdown a...
ORGANISM(S): Homo sapiens 
2020-04-22 | GSE146703 | GEO
TranscriptomicsRegulation of histone H3 by the ubiquitin-conjugating enzyme UBE2K determines neurogenesis of human embryonic stem cells [RNA-Seq]
We find that loss of UBE2K leads to accumulation of histone leading to increase in overall load for epigenetic marks and thus hindering differentiation.Our results provide a novel link between ubiquitination, histone regulation and hESC differentiation into neurons. To test whether UBE2K knockdown a...
ORGANISM(S): Homo sapiens 
2020-04-22 | GSE146701 | GEO
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