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ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
ProteomicsUbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains encode signals defining the fates of their modified proteins. Ubiquitin chain-mediated proteasomal degradation is a widespread eukaryotic regulatory mechanism. Yet, heterogeneity of intracellular ubiquitination has precluded systematically comparing degradation capacities of differe...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD060731 | Pride
Ubiquitin K48 Deubiquitination K63 Protein degradation Proteasome Proteostasis Electroporation Ubiquitin code Branched ubiquitin chains 
GenomicsA combinatorial ubiquitin code degrades substrates protected by deubiquitylation
A combinatorial ubiquitin code degrades substrates protected by deubiquitylation
PRJNA1141143 | ENA
UnknownAn expanded lexicon for the ubiquitin code.
Not available
S-EPMC9595094 | biostudies-literature
ProteomicsLinkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin chain architectures guide the binding events and itineraries of modified substrates. Various combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide bonds between the C-terminu...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD021286 | Pride
Proteomics Ubiquitin 
UnknownExpanding the ubiquitin code through post-translational modification.
Not available
S-EPMC4576978 | biostudies-literature
GenomicsDeciphering the SUMO code in plants
Deciphering the SUMO code in plants
PRJNA1148947 | ENA
TranscriptomicsA combinatorial ubiquitin code degrades substrates protected by deubiquitylation
Reversibility of protein ubiquitylation play essential roles in cellular protein homeostasis. How substrates stabilized by deubiquitylation are directed for degradation remains largely elusive. Here, we show that the branched ubiquitin chains promote the degradation of the deubiquitylase (DUB) OTUD5...
ORGANISM(S): Homo sapiens 
2025-02-19 | GSE273273 | GEO
UnknownUbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains.
Not available
S-EPMC7617769 | biostudies-literature
UnknownDecoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex.
Not available
S-EPMC9831982 | biostudies-literature
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