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ProteomicsAlterations in proteome and proteostasis networks during replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a ce...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD069085 | Pride
Ubiquitin profilling Replicative senescence 
TranscriptomicsMicroarray analysis of gene expression in CD4+CD8+ double pos (DP) thymocytes upon depletion of Ubiquitin specific protease 8
T-cell-specific deletion of USP8 (USP8ffCD4Cre) revealed that USP8 is required for thymocyte transition to the CD4+ and CD8+ single positive (SP) stages. To evaluate underlying mechanisms, gene expression profilling was performed in CD4+CD8+ double pos thymocytes derived from control (USP8ff and USP...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55517 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in CD4+CD8+ double pos (DP) thymocytes upon depletion of Ubiquitin specific protease 8
T-cell-specific deletion of USP8 (USP8ffCD4Cre) revealed that USP8 is required for thymocyte transition to the CD4+ and CD8+ single positive (SP) stages. To evaluate underlying mechanisms, gene expression profilling was performed in CD4+CD8+ double pos thymocytes derived from control (USP8ff and USP...
ORGANISM(S): Mus musculus 
2014-03-04 | GSE55517 | GEO
GenomicsS. cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase, modulates sensitivity to cell wall stressors through multiple transcription factors
S. cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase, modulates sensitivity to cell wall stressors through multiple transcription factors
PRJNA1111539 | ENA
GenomicsMus musculus
Microarray analysis of gene expression in CD4+CD8+ double pos (DP) thymocytes upon depletion of Ubiquitin specific protease 8
PRJNA239829 | ENA
Transcriptomicspad4 vs. pad4 est1b
This experiment was designed to identify transcripts which are changed in plants deficient for evolutionary conserved EST1B gene. A mutation in est1b leads to a constitutive up-regulation of a PAD4-dependent pathogen response pathway. To eliminate secondary effects of the constitutive pathogen respo...
ORGANISM(S): Arabidopsis thaliana 
2009-11-17 | E-GEOD-18979 | biostudies-arrayexpress
GenomicsUSP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
PRJNA1292019 | ENA
ProteomicsobABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors
Deubiquitinases (DUBs), and the dysregulation thereof, are implicated in human disease. The recent inclusion of selective DUB inhibitors in clinical trials has heightened interest in DUB-focused drug discovery. Current DUB screening methods remain constrained, however, as they often rely on recombin...
ORGANISM(S): Homo sapiens (Human) 
2026-10-09 | PXD064209 | Pride
Lc-ms/ms Otud7b Inhibitor Activity-based probe profilling (abpp) Usp5 Deubiquitinase Usp47 Deisgylase Ubiquitin Screen Usp7 
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