Sort   by:  
 Page size 
GenomicsThe Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and ...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-59518 | biostudies-arrayexpress
ProteomicsQuantitative proteomics reveals extensive lysine ubiquitination in Arabidopsis thaliana
In this study, we describe an antibody-based approach to enrich ubiquitinated peptides from vegetative tissues for detection via peptide mass spectrometry. This enrichment method can be coupled with isobaric labeling to enable quantification from up to 18-multiplexed samples. This approach identifie...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2024-07-31 | MSV000095496 | MassIVE
ProteomicsDeciphering NAC53, NAC78 interactome in response to Pst infection; NAC53, NAC78, MDP25 subcellular interactomes and identifying ubiquitination sites of NAC53 and NAC78 upon HRD1 E3 ligase mediated ubiquitination.
Analysis of NAC53 and NAC78 interactome in normal condition or upon Pseudomonas syringea pv. tomato DC3000 ∆HopQ infection. Constructs promUBQ10::eGFP-NAC53/eGFP-NAC78 are used as baits and promUBQ10::eGFP is used as control. Analysis of ubiquitination sites on NAC53 and NAC78 upon HRD1a/b ubiquitin...
ORGANISM(S): Nicotiana benthamiana 
2026-03-23 | PXD075538 | Pride
Ap-ms Interactome Ubiquitination Subcellular localization Bacterial infection Transcription factors Microtubule depolymerizing factor 
GenomicsChIP-seq analysis of PHF20 and Wdr5 binding sites in ESCs
Although reprogramming of somatic cells to generate inducible pluripotent stem cells (iPSCs) is associated with remarkable epigenetic changes, the role and mechanisms of epigenetic factors in this process remains poorly understood. Here we describe identification of Jmjd3 as a potent negative regula...
ORGANISM(S): Mus musculus 
2013-12-06 | E-GEOD-43247 | biostudies-arrayexpress
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
ProteomicsCytoplasmic lattices are megadalton storage complexes for tubulin and ubiquitination factors in mammalian oocytes 
Mammalian oocytes store proteins for embryonic development on abundant structures known as cytoplasmic lattices (CPLs); however, the mechanisms by which they achieve this are unclear, largely because the molecular composition of the lattices themselves is unknown. Here, we use cryo-electron microsco...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-11 | PXD073451 | Pride
Maternal storage Cryo-electron microscopy Tubulin Cytoplasmic lattices Ubiquitination factors 
TranscriptomicsSHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the activities of p63 and Hypoxia-Inducible-Factors (HIFs), two master regulators of the invasive and metastatic cancer cell phenotype are linked in TNBC ...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-33950 | biostudies-arrayexpress
ProteomicsInhibition of MUL1-mediated ubiquitination promotes mitochondria-associated translation
G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13. Previous studies have associated GPS2-mediated restriction of K63 ubiquitination with the regulation of insulin signaling, inflammatory responses and mitocho...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD030187 | Pride
Lc-msmubiquitin I.e. human Pabpc Mitochondria stress response (msr)s Plasma Mitochondria Mul1 Gps2 Liver 
UnknownReconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.
Not available
S-EPMC4175178 | biostudies-literature
GenomicsNascent-protein ubiquitination is required for heat shock-induced gene downregulation in human cells.
Nascent-protein ubiquitination is required for heat shock-induced gene downregulation in human cells.
PRJNA445860 | ENA
Sort   by:  
 Page size