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ProteomicsChemical Genetic Identification of Cyclin-G-associated kinase (GAK) Substrates Reveals its Role in Regulating Na+/K+-ATPase and Sipa1L1 in Neurons
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a Parkinson’s disease risk. However, its role in neuronal function and many downstream effectors remain unclear. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-07 | PXD011319 | Pride
Cyclin-g-associated kinase Sodium potassium pump Atp1a3 Gak 
ProteomicsLoss of NDR1/2 kinases impairs endomembrane trafficking and ATG9A localisation, reduces autophagy and leads to neurodegeneration
Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases implicated in neuronal development, mitochondrial health and autophagy, but how they affect mammalian brain development in vivo is not known. Usi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-21 | PXD035566 | Pride
Autophagy Ndr1/2 Atg9a Neurodegeneration 
ProteomicsPhosphoproteomics reveals altered RNA splicing as a major potential driver of pathology in the brain in tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in the genes TSC1 and TSC2, resulting in activation of mechanistic target of rapamycin complex 1 (mTORC1). Neurological manifestations occur in most TSC patients and include epilepsy, autism and intellectual disability. Two types...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD069405 | Pride
Tmtpro Rna processing Tsc Human Segas Tubers Mtor 
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