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MetabolomicsUrinary Extracellular Vesicle Metabolomic Profiling Reveals a Distinct Molecular Signature for the Non-Invasive Diagnosis of Lupus Nephritis

Background: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), underscoring an urgent need for non-invasive diagnostic biomarkers. 

Objective: This study aimed to define the metabolomic signature of urinary e...

2026-02-11 | MTBLS13839 | MetaboLights
ProteomicsProteome-scale correlation analysis between urinary extracellular vesicle (uEV) and kidney
We profiled the proteomes of uEV and kidney from twelve rats. Six of them were under a standard diet while the other six under a high potassium diet for 4 days. During the revision stage of this project, we further put five rats in metabolic cages for two days, fed with the high potassium diet for 2...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-27 | PXD018363 | Pride
Urinary extracellular vesicle (uev) Kidney Correlation Proteome 
ProteomicsHuman urinary extracellular vesicles protein LC-MS/MS
Urinary extracellular vesicles (uEV) are a precious new source of biomarkers reflecting the physiological state of the upstream parent cells and organ systems. However, urinary Tamm-Horsfall Protein (THP; uromodulin) interferes heavily with all vesicle isolation attempts, precipitates with normal ur...
ORGANISM(S): Homo sapiens (Human) 
2019-09-30 | PXD013429 | Pride
Urea Mass spectrometry Tamm-horsfall protein Urinary extracellular vesicle Biomarker 
ProteomicsComparative mass spectrometry analysis of high centrifugation vs. low centrifugation uEV pellets following THP removal
Urinary extracellular vesicles (uEVs) denote minuscule membranous entities generated by cells lining the urinary tract and adjoining tissues(1). The examination of uEVs as an exploratory instrument has garnered substantial focus owing to their prospective utility as non-invasive biomarkers for diagn...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064844 | Pride
Urinary extracellular vesicles Fractionation Proteasome 
GenomicsUrinary Extracellular Vesicle Whole-Transcriptome Analysis in Diabetic Nephropathy
Urinary Extracellular Vesicle Whole-Transcriptome Analysis in Diabetic Nephropathy
PRJNA906149 | ENA
TranscriptomicsTranscriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
One of the challenges of current research in prostate cancer is to improve the differential non-invasive diagnosis of prostate cancer (PCa) and benign prostate hyperplasia (BPH). Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In additio...
ORGANISM(S): Homo sapiens 
2016-01-13 | E-GEOD-75441 | biostudies-arrayexpress
ProteomicsSize matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients
Glioblastoma is a fatal and devastating primary brain tumour that poses significant challenges to accurate tumour monitoring and patient treatment. Substantial efforts are underway to develop accurate non-invasive liquid biopsy methods that can routinely assess glioblastoma markers in patient body f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051553 | Pride
Gliioblastoma Extracellular vesicles Liquid biopsy Urine 
UnknownComparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease.
Not available
S-EPMC7789228 | biostudies-literature
UnknownSingle urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.
Not available
S-EPMC12307914 | biostudies-literature
ProteomicsProteomic Analysis of Urinary Extracellular Vesicles from Patients with ADTKD-HNF1β identifies roles for cilia-related proteins and Serpins
Autosomal dominant tubulointerstitial kidney disease-subtype hepatocyte nuclear factor 1β (ADTKD-HNF1β) is caused by pathogenic variants in or deletions of the gene encoding transcription factor HNF1β. Patients with the same mutation have variable renal and extrarenal phenotypes, including renal cys...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD050720 | Pride
Urine Cilia Serpins Ckd Extracellular vesicles Adpkd Adtkd-hnf1b 
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