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The identification of new agents that may modulate the progression of cancer cell growth is of great interest. In this regard, dietary agents can be utilized to identify molecular targets to be used as part of a chemopreventive strategy. Walnuts contain several bioactive compounds, including peduncu...
ORGANISM(S): Homo sapiens 
Urolithin A is a polyphenol derived from the multi-step metabolism of dietary ellagitannins by the human gut microbiota which can affect host health. Most, but not all, individuals harbor a microbiota capable of urolithin A production; however, the enzymes that dehydroxylate its dietary precursor, u...
ORGANISM(S): Enterocloster bolteae ATCC BAA-613 Bacteria 
2024-12-16 | PXD048514 | Pride
Urolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity. A single 9-hydroxy urolithin dehydroxylase (ucd) operon in gut re...
ORGANISM(S): Enterocloster hominis (ex Hitch et al. 2024) Enterocloster citroniae Enterocloster asparagiformis Bacteria 
2025-11-12 | PXD066865 | Pride
This study investigates the synergistic antitumor efficacy of a triple combination therapy—Nisin (N), Urolithin B (UB), and Vincristine (Vinc)—against human HBK11 lymphoma cells, with an emphasis on proteomic mechanisms of action. The findings elucidate the molecular underpinnings of this novel comb...
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD065631 | Pride
Determining effects of microbial metabolite, Urolithin A on colon epithelial cells
Effect of IAPP insult and urolithin B treatment in beta-cell gene expression
Effects of urolithin B treatment on gene expression of IAPP-expressing yeast cells
To investigate the effects of IAPP insult and urolithin B treatment in the gene expression of a rodent cell line, we submitted the cells to different treatments: control, urolithin B, IAPP, annd urolithin B+IAPP
ORGANISM(S): Rattus norvegicus 
2025-12-31 | GSE218150 | GEO
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