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ProteomicsDefining the Human Lung Pathodegradome of the V8 Protease from Staphylococcus aureus-gel digest
Staphylococcus aureus is a globally relevant human pathogen and key driver of human morbidity and mortality. During infection it employs a suite of extracellular proteases to subvert host defenses and promote disease progression. Key amongst these, the V8 serine protease (SspA), stands out as a mast...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD070297 | Pride
Degradomics V8 protease Tags-cr Staphylococcus aureus 
ProteomicsDefining the Human Lung Pathodegradome of the V8 Protease from Staphylococcus aureus
Staphylococcus aureus is a globally relevant human pathogen and key driver of human morbidity and mortality. During infection it employs a suite of extracellular proteases to subvert host defenses and promote disease progression. Key amongst these, the V8 serine protease (SspA), stands out as a mast...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD070241 | Pride
Degradomics V8 protease Tags-cr Staphylococcus aureus 
ProteomicsInsight into the Human Pathodegradome of the V8 protease from Staphylococcus aureus
The major human pathogen Staphylococcus aureus possesses ten extracellular proteases that are central to the virulence process. While some host targets of these and other bacterial proteases are known, a major bottleneck to the study of their function is the low-throughout nature of substrate identi...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2021-03-29 | PXD014797 | Pride
Host-pathogen interactions Immunology Microbiology N-terminomics Staphylococcus aureus Degradomics 
ProteomicsDevelopment of a New N-Terminomic Method to Study the Pathodegradome of the Staphylococcus aureus V8 Protease in Human Neutrophils
Staphylococcus aureus is a notorious human pathogen that relies on an array of virulence factors to engender infection and evade the host-immune system. Among these are the secreted proteases, which promote pathogenesis by degrading host proteins and modulating host-defenses. Human neutrophils play ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD057579 | Pride
Degradomics Neutrophils Tags-cr Immune dysregulation. Staphylococcus aureus V8 protease 
ProteomicsDevelopment of a New N-Terminomic Method to Study the Pathodegradome of the Staphylococcus aureus V8 Protease in Human Neutrophils
Staphylococcus aureus is a notorious human pathogen that relies on an array of virulence factors to engender infection and evade the host-immune system. Among these are the secreted proteases, which promote pathogenesis by degrading host proteins and modulating host-defenses. Human neutrophils play ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD057551 | Pride
Degradomics Neutrophils Tags-cr Immune dysregulation. Staphylococcus aureus V8 protease 
UnknownInsight into the human pathodegradome of the V8 protease from Staphylococcus aureus.
Not available
S-EPMC8054439 | biostudies-literature
UnknownS. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
Not available
S-EPMC10669764 | biostudies-literature
ProteomicsOne-step Isolation of Protein C-terminal Peptides from Protease-digested Proteins by Metal Oxide-based Ligand Exchange Chromatography
We have developed a one-step method to isolate protein C-terminal peptides from V8-digested proteins by metal oxide-based ligand-exchange (MOLEX) chromatography. V8 protease cleaves the C-terminal side of Asp and Glu, and the resulting digested peptide has two carboxy groups at the C-terminus, where...
ORGANISM(S): Homo Sapiens (human) 
2021-12-28 | PXD027960 | JPOST Repository
UnknownDevelopment of a new N-terminomic method to study the pathodegradome of the <i>Staphylococcus aureus</i> V8 protease in human neutrophils.
Not available
S-EPMC12282195 | biostudies-literature
ProteomicsPeptidomic analysis of endogenous and bacterial protease activity in human plasma
The clinical assessment of wound infection and related complications is challenging and the development of objective methods to measure wound status and predict healing outcomes is therefore essential. As endogenous and bacterial protease activities play important roles in healing and infection, ana...
ORGANISM(S): Homo sapiens (Human) 
2024-03-07 | PXD037245 | Pride
Human Lc-msms Plasma Proteases Peptidome 
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