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ProteomicsA Bothrops jararaca venom subproteome to benchmark a spectral clustering algorithm by controlling the selection bias
The clustering of mass spectra is a critical component of many proteomics applications. The clustering validation science is just as important, having evolved side by side with the clustering algorithms themselves. In this work, we build on Rieder et al. 's cluster validation framework, and we discu...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2022-03-16 | PXD022124 | Pride
Bothrops jararaca Venomics Spectral clustering Algorithm 
ProteomicsGlycolytic profile shift and antioxidant triggering in symbiont-free and H2O2-resistant Strigomonas culicis
During their life cycle, trypanosomatids are exposed to stress conditions and adapt their energy and antioxidant metabolism to colonize their hosts. Strigomonas culicis is a monoxenous protist found in invertebrates with an endosymbiotic bacterium that completes essential biosynthetic pathways for t...
ORGANISM(S): Strigomonas culicis 
2019-11-27 | PXD015717 | Pride
Energetic metabolism Ascorbate peroxidase Pentose phosphate pathway Antioxidant system Oxidative stress 
ProteomicsMolecular mechanisms underlying intraspecific variation in snake venom
Elucidating the molecular mechanisms underlying snake venom variability provides important clues for understanding how the biological functions of this powerful toxic arsenal evolve. We analyzed in detail individual transcripts and venom protein isoforms produced by five specimens of a venomous snak...
ORGANISM(S): Bothrops atrox 
2023-07-04 | PXD043541 | Pride
Plasticity Snake venom Toxin function Proteome Evolution Transcriptome 
ProteomicsQuantitative proteomic map of the trypanosomatid Strigomonas culicis: the biological contribution of its endosymbiotic bacterium
Strigomonas culicis is a kinetoplastid parasite of insects that maintains a mutualistic association with an intracellular symbiotic bacterium, that is highly integrated into the protozoa metabolism: it furnishes essential compounds and divides in synchrony with the nuclear host. The protozoa, conve...
ORGANISM(S): Strigomonas culicis 
2019-11-08 | PXD013136 | Pride
Endosymbiont-bearing trypanosomatid  proteomics  mass spectrometry  amino acid metabolism Protein synthesis And folding  energetic metabolism 
ProteomicsMebendazole Inhibits Histoplasma capsulatum In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels
Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if treatment is unsuccessful. Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potential...
ORGANISM(S): Fungi Histoplasma capsulatum 
2023-03-22 | PXD033762 | Pride
Histoplasma capsulatum  mebendazole  drug repositioning. antifungal activity Proteomic analysis 
ProteomicsProteomics reveals virulence-related proteins in Paracoccidioides brasiliensis and Paracoccidioides lutzii yeast cells grown in the presence of L-dihydroxyphenylalanine
Species of the genus Paracoccidioides cause a systemic infection in human patients. Yeast cells of Paracoccidioides spp. produce melanin in the presence of L-dihydroxyphenylalanine and during infection, which may impact the pathogen survival into the host. To better understand the metabolic changes ...
ORGANISM(S): Fungi Paracoccidioides brasiliensis (strain Pb18) Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) 
2021-01-20 | PXD021711 | Pride
L-dihydroxyphenylalanine Proteomics Virulence Melanin Paracoccidioides 
ProteomicsMannose-6-phosphate isomerase functional status shapes a rearrangement in the proteome and degradome of mannose-treated melanoma cells
Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cells to convert mannose-6-phosphate into fructose-6-phosphate, t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-16 | MSV000094098 | MassIVE
ProteomicsEndosymbiont elimination enhances de novo heme synthesis by the overexpression of a ferrous iron transporter in Strigomonas culicis
The monoxenous trypanosomatid Strigomonas culicis inhabits several mosquito species, including Aedes aegypti. Previously, our group described that the infection of A. aegypti females by this trypanosomatid triggers the insect's immune response, reduces its reproductive fitness, and could potentially...
ORGANISM(S): Candidatus Kinetoplastidibacterium Blastocrithidiae (ex Strigomonas Culicis) Strigomonas Culicis 
2026-01-12 | PXD044748 | panorama
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