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ProteomicsLC-MS/MS identification of differentially expressed proteins in carboplatin resistant Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is the subtype of breast cancer most lacking in efficient treatment options. Although many TNBCs show remarkable responses to carboplatin-based chemotherapy, they often develop resistance over time. With increasing use of carboplatin in clinics, there is a pressi...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD021726 | Pride
Lc-ms/ms identification of differentially expressed proteins in carboplatin resistant triple negative breast cancer 
ProteomicsLC-MS/MS shotgun proteome analysis of Saccharomyces cerevisiae lysates
N-terminal acetylation is a highly abundant protein modification in eukaryotes which impacts a wide range of cellular processes and protein properties. This modification was proven to be essential for development and viability of multiple eukaryotes. Still the molecular mechanisms at play and the pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-11-15 | PXD009214 | Pride
Tandem mass spectrometry Saccharomyces cerevisiae N-terminal acetylation 
ProteomicsEnvironmental conditions steer phenotypic switching in AHPND-causing Vibrio parahaemolyticus, affecting PirABVP toxin production
Bacteria in nature are widely exposed to differential fluid shears which are often a trigger for phenotypic switches. The latter mediates transcriptional and translation remodeling of cellular metabolism impacting among others virulence, antimicrobial resistance and stress resistance. In this study,...
ORGANISM(S): Vibrio parahaemolyticus 
2020-02-05 | PXD015617 | Pride
Virulence Biological features Vibrio parahaemolyticus Fluid shear Phenotype switching Antimicrobial resistance 
ProteomicsAn Unexpected Encounter: Respiratory Syncytial Virus Non-Structural Protein 1 Interacts With Mediator Subunit MED25
Human respiratory syncytial virus (RSV) is the leading cause of severe acute lower respiratory tract infections in infants worldwide. Non-structural protein NS1 of RSV modulates the host innate immune response by acting as an antagonist of type I and type III interferon (IFN) production and signalin...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD034627 | Pride
Mass spectrometry Proximity labeling Protein-protein interaction Respiratory syncytial virus Non-structural protein 
ProteomicsIdentification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics
MuRF1 is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy. In this study, we used in vivo electroporation ...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD023872 | Pride
Ubiquitin proteomics Muscle atrophy Murf1 Protein degradation Electroporation 
ProteomicsRhoJ controls EMT associated resistance to chemotherapy
The resistance of cancer cell to therapy is responsible of the death of most cancer patients. Epithelial to mesenchymal transitions (EMT) has been associated with resistance to therapy in different cancer cells. However, the mechanisms by which EMT mediates resistance to therapy remain poorly unders...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-13 | PXD025737 | Pride
Cancer  emt  therapy resistance  rhoj 
ProteomicsComplementary peptides (cPEPs) modulate protein translation
MicroRNAs (miRNAs) are small regulatory RNAs that control plant and animal development by regulating post-transcriptional gene expression. Primary transcripts of miRNAs contain small ORFs that can be translated into small peptides (miPEPs). MiPEPs specifically enhance the expression of their cognate...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-01-09 | PXD017404 | Pride
Affinity purification Microrna Post-transcriptional regulation Complementary peptides 
ProteomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
NAA15 is a component of the NatA complex that acetylates amino terminal (Nt) protein residues and influences protein synthesis. We identified multiple damaging NAA15 variants in congenital heart disease patients, including four loss-of-function (LoF) variants, one missense (R276W) de novo variant an...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD017672 | Pride
Ipsc Shotgun proteomics Lc-ms/ms 
ProteomicsFat1 deletion promotes hybrid EMT state, tumor stemness, and metastasis
FAT1, a protocadherin, is among the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. In the present study we used different mouse cancer models including skin squ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022268 | Pride
Stemness Fat1 Hybrid emt Metastasis 
ProteomicsProteomic assessment of C57BL/6 hippocampi after non-selective pharmacological inhibition of all nitric oxide synthase activity
Nitric oxide is the smallest gaseous signaling molecule responsible for maintaining homeostasis in a myriad of tissues and molecular pathways in neurological and cardiovascular pathologies. In recent years, there has been increasing interest in the potential interaction between arterial stiffness (A...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD033646 | Pride
Lc-msms Hippocampus Nitric oxide Mouse 
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