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ProteomicsSILAC proteomics analysis to assess differences in protein expression upon BRCA2 inactivation
BRCA2 maintains genome stability by facilitating DNA repair via homologous recombination and replication fork stability. Loss of BRCA2 is deleterious for survival of normal cells, but is paradoxically tolerated in cancer cells. Using quantitative mass-spectrometry, differences in protein expression ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD007253 | Pride
Silac breast cancer brca2 hcc38 
UnknownThe Napoleon Complex: When Shorter Men Take More.
Not available
S-EPMC6247438 | biostudies-literature
UnknownCohort profile: The PharmAccess African (PASER-M) and the TREAT Asia (TASER-M) monitoring studies to evaluate resistance--HIV drug resistance in sub-Saharan Africa and the Asia-Pacific.
Not available
S-EPMC3304520 | biostudies-literature
ProteomicsSILAC proteomics analysis to discover effect sensors of EGFR inhibition
Targeted therapies against EGFR show clinical benefit, but resistance to these agents invariably develops. Thus, there is a need for dynamic biomarkers - effect sensors - that reflect treatment with EGFR therapeutics during therapy. Making use of SILAC-labeling we aimed to discover plasma membrane p...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD005985 | Pride
Egfr silac breast cancer biomarkers erlotinib 
UnknownExperiencing a Severe Weather Event Increases Concern About Climate Change.
Not available
S-EPMC6378300 | biostudies-literature
ProteomicsTime-course SILAC proteomics to determine the response to WEE1i in RPE-1 WT vs EIF2A-KO RPE-1 cells
AZD1775 is an ATP-competitive inhibitor of WEE1 protein kinase. Inhibition of WEE1 causes hyperactivation of CDK1 and CDK2, which leads to premature mitosis and DNA replication stress. AZD1775 has been evaluated in patients with relapsed high grade serous ovarian cancer (HGSOC) and has shown promisi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD054741 | Pride
Human ovarian wee1 eif2a hgsoc 
ProteomicsThe FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin
Joint DNA molecules are natural by-products of DNA replication and repair. Persistent joint molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, which compromise sister chromatid separation. The DNA translocase PICH (ERCC6L) plays a central role in UFB resolution. To better understand the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD035876 | Pride
Homologous recombination rad51 c1orf112 dna repair flag ip 
ProteomicsSister chromatid exchanges independent of canonical homologous recombination factors.
Sister chromatid exchanges (SCEs) are a product of joint DNA molecules resolution, and are considered to require homologous recombination (HR). Canonical HR factors BRCA1, BRCA2 and RAD51 were indeed essential for SCE induction in response to irradiation-induced DNA breaks. By contrast, replication-...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-03-11 | PXD028670 | Pride
Cross-over Interphase Xenopus laevis Ms Mitosis Hr Sce Synthetic lethality Parp inhibitors Genome stability Biotin 
UnknownNuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.
Not available
S-EPMC5082896 | biostudies-literature
UnknownAn add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis - A proof of concept trial.
Not available
S-EPMC6886760 | biostudies-literature
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