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ProteomicsRICTOR/mTORC2 downregulation in BRAF V600E melanoma cells promotes resistance to BRAF/MEK inhibition
Background Main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF- mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to define in this context the specific role of mTORC2, a signaling complex defined by the pr...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD050614 | Pride
Targeted therapy Rictor Braf v600e melanoma Mitochondrial metabolism Drug resistance Nampt Mtorc2 
ProteomicsProtein Extraction methods suitable for muscle tissue proteomic analysis
• Evaluation of two methods for protein extraction from muscle tissues. • Two different extraction methods showed distinct patterns of protein abundance; • Two-dimensional electrophoresis revealed 131 spots with different volumes; • SDS-based buffer (method A) mostly extracted proteins of high MW r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053117 | Pride
Mass spectrometry Protein denaturation Muscle tissue Two-dimensional electrophoresis Myopathies. 
ProteomicsProteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers
Non-Muscle Invasive Bladder Cancer (NMIBC) includes High-Grade (HG) and Low-Grade (LG) variants, classified by aggressiveness, recurrence risk, and tumor stage—either non-invasive (pTa) or invading the lamina propria (pT1). Cystoscopy is the diagnostic gold standard, with no less invasive alternativ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069436 | Pride
Nmibc  tumor stage  proteomics  prognostic markers  pdc6i 
ProteomicsMolecular Insights into Central Core Disease: Proteomic Signatures and Potential Therapeutic Biomarkers in RYR1 I4895T Mice
Central Core Disease (CCD) is a congenital myopathy, predominantly caused by mutations in the gene encoding for ryanodine receptor type-1(RYR1), the intracellular Ca2+ release channel embedded in skeletal muscle sarcoplasmic reticulum membrane. One of the most common RYR1 mutations associated to CCD...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD069980 | Pride
Oxidative phosphorylation Myosin fragments Central core disease Glycolysis Pgc1α 
ProteomicsSerum proteomic profile of asthmatic patients after 6 months of Benralizumab and Mepolizumab treatment
Severe eosinophilic asthma is characterized by chronic airway inflammation, oxidative stress and elevated proinflammatory cytokines, especially IL-5. Mepolizumab and benralizumab are both humanized IgG antibodies directed against IL-5 signaling, directly acting on eosinophils count. Together with th...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD029793 | Pride
Apoc Severe eosinophilic asthma. Mepolizumab  benralizumab  ceruloplasmin  plasminogen  apoa1 
ProteomicsBAL proteomic signature of lung adenocarcinoma in IPF patients and its transposition in serum samples for less invasive diagnostic procedures
Idiopathic pulmonary fibrosis (IPF) is a form of chronic and irreversible fibrosing interstitial pneumonia of unknown aetiology, with an average survival time of 3-5 years after diagnosis. Emerging evidence suggests that IPF increases the risk of lung carcinogenesis. Both diseases show similarities ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037720 | Pride
Ipf Lung cancer Proteomics Apolipoprotein e Nampt Calgranulin b Biomarkers Bal Profilin 1 Apolipoprotein a1 
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