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ProteomicsEstablishment and characterization of a 3D model culture system of primary human ovarian cells: Silk-Ovarioids
In vitro models that mimic ovaries are instrumental in unraveling physio-pathological mechanisms underlining follicle activation and growth. Three-dimensional (3D) systems that replicate the heterogeneity and cell-cell communication among different ovarian cell types are biologically most relevant. ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048710 | Pride
3d model Proteomics Ovaroids 
ProteomicsThe proteome of osteoblasts in a 3D culture bioreactor model with static and perfusion conditions using biomimicry
Disorders influencing bone form a major burden worldwide, with osteoporosis being the most common fracture-inducing bone disease. Currently, animal models are being utilized to develop and screen novel treatments. However, due to interspecies variations, different microenvironments, and ethical cons...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057937 | Pride
Human fetal osteoblastic cells Proteomics And regenerative medicine Bioreactor Bone Tissue engineering 
ProteomicstRNA regulation and amino acid usage bias reflect a coordinated metabolic adaptationin Plasmodium falciparum
An adaptive feature of malaria-causing parasites is the digestion of host hemoglobin (HB) to acquire amino acids (AAs). Here, we describe a link between nutrient availability and translation dependent regulation of gene expression as an adaptive strategy. We show that tRNA expression in Plasmodium f...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD056396 | Pride
Plasmodium falciparum 
ProteomicsPyruvate kinase supports the metabolic shift and long-term survival of a mouse model with mitochondrial dysfunction caused by DGUOK deficiency
The deoxyguanosine kinase (DGUOK) deficiency causes mtDNA depletion and mitochondrial dysfunction. We reported prolonged survival of Dguok knockout (Dguok-/-) mice despite low (<5%) mtDNA content in the liver. However, the molecular mechanisms, enabling the extended survival, remain unknown. Using t...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023881 | Pride
Mouse Label-free quantification Tmt-based quantification Dguok deficiency 
ProteomicsBacterial EVs as intranasal postbiotics: Detailed characterization and interaction with airway cells
Escherichia coli A0 34/86 (EcO83) is a probiotic bacterium used in newborns to prevent nosocomial infections and diarrhoea. Mechanistically, EcO83 induces the production of pro- and anti-inflammatory cytokines in vitro and in vivo and, when administered intranasally, inhibits allergic airway inflamm...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD052553 | Pride
Macrophage Postbiotic Nitric oxide Nf-κβ signalling Probiotic Bacterial extracellular vesicles 
ProteomicsNetwork Analysis Reveals Age- and Virus-Specific Circuits in Nasal Epithelial Cells of Extremely Premature Infants
Viral respiratory infections significantly affect young children, particularly extremely premature infants, resulting in high hospitalization rates and increased health-care burdens. Despite posing substantial health risks, airway immune responses in early life remain largely unexplored. Nasal epith...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD042209 | Pride
Nasal epithelial cells Premature infants Virus-specific pathways 
ProteomicsProteomic Analysis of the Urothelial Cancer Landscape
Urothelial cancer is a challenging disease with a wide tumor-biological spectrum. Most molecular classification attempts are transcriptome-based and relate only indirectly to the therapeutically relevant protein level. We improve preanalytical preparation of clinical samples for proteome analyses an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD041268 | Pride
Urothelial cancer  bladder cancer  molecular classification  pathology  urological oncology  urology  oncology  drug prediction  proteomics  protein extraction  clinical proteomics  risk stratification  molecular oncology  diagnostics  personalized medicine  personalized oncology  translational pathology  predictive testing 
ProteomicsSARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in hamster model
Seeking a nuanced understanding of host tissue-specific responses and their implications for immunopathogenicity against the SARS-CoV-2 infection was convoluted and not evaluated earlier. We delved into the intricacies of using to understand the complex relationship among acute multi-tissue injury, ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2026-01-05 | PXD048058 | Pride
Omics Sars-cov-2 Delta Hamster model Omicron Acute covid-19 Pasc Gut-lung-brain axis Tissue-response 
ProteomicsHuman Gingival Crevicular Fluid Reveals the Occurrence of Ferroptosis During Clinical Progression of Periodontitis
Thirteen healthy men diagnosed with periodontitis were enrolled. Progression of periodontitis was monitored by clinical attachment level (CAL) changes at the site level over twelve weeks via weekly clinical evaluations and gingival crevicular fluid (GCF) samples were collected using cellulose strips...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046328 | Pride
Crevicular fluid Disease progression Periodontitis 
ProteomicsConstitutional variants and tumor-specific down-regulation of the calcium voltage-gated channel subunit CACNA1H in pheochromocytoma
Pheochromocytoma (PCC) and abdominal paraganglioma (aPGL) (together abbreviated PPGL) frequently present with an underlying genetic event in a PPGL driver gene, and additional susceptibility genes are anticipated. Here we re-analysed whole-exome sequencing data for PCC patients, and identified two p...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-17 | PXD040446 | Pride
Calcium channel Pheochromocytoma Paraganglioma Cacna1h 
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