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ProteomicsMitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to PGE2
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here we show that PGE2 causes mitochondrial membrane potential (Δψm) to dissipate in interleukin-4 activated macrophag...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD010997 | Pride
Macrophage Prostaglandin e2 Camp Got1 Malate-aspartate shuttle Immunometabolism Mitochondrial membrane potential Etv1 Alternative activation Il-4 
UnknownPolyamine metabolism is a central determinant of helper T cell lineage fidelity.
Not available
S-EPMC8358979 | biostudies-literature
ProteomicsVitamin D₃ metabolites as complementary alternatives to antibiotics in bovine mastitis
In this study, we performed a focused in vitro comparison of vitamin D₃, 25(OH)D₃, and 1,25(OH)₂D₃ to assess their differential effects on proteomic markers associated with the vitamin D pathway in bovine mammary cells. This targeted analysis aims to identify protein-level signatures that clarify th...
ORGANISM(S): Bos taurus (Bovine) 
2026-05-02 | PXD071673 | Pride
1 Innate immunity 25-dihydroxyvitamin d₃ Bovine mammary gland Label-free quantification Mastitis Cholecalciferol (vitamin d₃) 25-hydroxyvitamin d₃ 
ProteomicsProteomic dataset of Wt and PTPMT1 KO regulatory T cells
Mitochondrial defects are emerging as key drivers of gut inflammation, colitis, and IBD. Yet, their role in regulating immune tolerance, fine-tuned by helper T cells, is unclear. Understanding how metabolic changes in T cells impact gut tolerogenic mechanisms, including gut colonization and the bal...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD060518 | Pride
Ptpmt1 Treg Cardiolipin 
ProteomicsProteomic dataset of Wt, PTPMT1 KO, CHOP KO and PTPMT1 CHOP double KO regulatory T cells
Mitochondrial defects are emerging as key drivers of gut inflammation, colitis, and IBD. Yet, their role in regulating immune tolerance, fine-tuned by helper T cells, is unclear. Understanding how metabolic changes in T cells impact gut tolerogenic mechanisms, including gut colonization and the bal...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD071483 | Pride
Ptpmt1 Treg Cardiolipin 
ProteomicsABCA7 transporter functional role on Alzheimer’s disease onset and progess
Identification of new drug targets and biomarkers with a true clinical potential to treat or at least modify the disease course of Alzheimer’s disease (AD) has become a major challenge. Despite newly identified, GWAS-derived risk factors for AD, this type of genetic information only represents the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053250 | Pride
Proteomics Mass spectrometry Abca7 : alzheimer’s disease Biomarkers Neurodegeneration Expression profiles Protein identification 
UnknownAn epigenetic clock for gestational age at birth based on blood methylation data.
Not available
S-EPMC5054584 | biostudies-literature
UnknownIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Not available
S-EPMC6559955 | biostudies-literature
UnknownThe European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.
Not available
S-EPMC11408602 | biostudies-literature
UnknownLarge-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Not available
S-EPMC3119261 | biostudies-literature
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