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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsProtein profile of vitreous from Reeler model
To provide information about candidate factors contributing to impaired retinogenesis that might be useful tool for alternative therapeutic strategies, proinflammatory/profibrogenic mediator were evaluated in the vitreous from Reelin deficient mice, a model characterized by impaired retinogenesis. V...
ORGANISM(S): Mus musculus 
2019-02-13 | E-MTAB-7622 | biostudies-arrayexpress
ProteomicsUveal Melanoma Human Vitreous Proteome
The purpose of the project was to profile protein expression liquid vitreous biopsies from uveal melanoma (UM) patients using mass spectrometry, to identify prognostic biomarkers, signaling pathways, and therapeutic targets. Vitreous biopsies were collected from two cohorts: comparative control eyes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043403 | Pride
Vitreous Uveal melanoma Human 
ProteomicsDifferential proteomes in the vitreous of mice with a chronic hypoxic response in photoreceptors
Reduced oxygenation of photoreceptors and the RPE in the ageing eye may be a risk factor for the development of both neovascular and dry AMD. Chronic activation of the molecular response to hypoxia in RPE or photoreceptors leads to retinal degeneration that depends on hypoxia inducible transcription...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-12 | PXD008911 | Pride
Retinal degeneration Vitreous Cones Rods Hypoxic response Amd Shot-gun proteomics 
MetabolomicsProteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control

Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) has been implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems have limited mechanistic insight. Here, we applied a multi-omics approach in cells ectopically expressing the ISGyl...

2026-03-02 | MTBLS12619 | MetaboLights
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
ProteomicsValidation of potential growth-related proteins in chick vitreous during emmetropization using targeted-based proteomics (MRMHR)
The relatively new high-resolution MRM (MRMHR) approach with the Triple-TOF MS running under nanoflow was adopted in this study to solidify further the findings of SWATH-MS results of differentially expressed proteins found across the time points in the chick vitreous for the benefit of low peptide ...
ORGANISM(S): Gallus gallus (Chicken) 
2024-09-25 | PXD056184 | Pride
Vitreous Swath-ms Mrmhr 
ProteomicsProteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are leading causes of visual impairment and blindness in people aged 50 years or older in middle-income and industrialized countries. Anti-VEGF therapies have improved the management of neovascular AMD (nAMD) and proliferative DR (...
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD038285 | Pride
Complement and coagulation cascades Age-related macular degeneration Neurodegeneration Vitreous proteomics. Extracellular matrix Proliferative diabetic retinopathy Biomarkers Retinal detachment 
ProteomicsHuman PDR Vitreous Variability Study, TMT-MS
Control (n=27) and proliferative diabetic retinopathy (n=23) vitreous samples were treated as biologically distinct individuals or pooled together and aliquoted into technical replicates. Quantitative mass spectrometry with tandem mass tag labeling was used to identify proteins in individual or pool...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD025986 | Pride
Proliferative diabetic retinopathy Vitreous Tmt-ms Human 
ProteomicsProteomic analysis of human vitreous humor
In this study, we investigated the proteome of normal human vitreous humor using high resolution Fourier transform mass spectrometry. We identified 1269 proteins. This largest catalog of vitreous proteins to date should facilitate biomedical research into pathological conditions of the eye including...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD000957 | Pride
Retina Body fluid proteomics Protein biomarkers 
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