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TranscriptomicsEffect of von Willebrand factor on gene expression in HUVECs
Von Willebrand factor is a paracrine/autocrine regulator of human mesenchymal stem cell adhesion to distressed/apoptotic endothelial cells. This data set examines effect of vWF on gene expression in HUVECs. HUVECs were maintained in EGM2 media and treated with vWF in Hank's buffered salt solution (...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-19816 | biostudies-arrayexpress
ProteomicsMechano‐covalent protection 1 of procoagulant factor VIII by von Willebrand factor
von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half‐life and delivering it to the developing thrombus. VWF∙FVIII complex formation is characterized by catch‐bond behavior in which force first decelerat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD034866 | Pride
Cysteines Factor fviii Von willebrand factor Disulphide bonds 
ProteomicsVon Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor to GPIbα on platelets to form a platelet plug. A1 is activated by tensile force on VWF concatemers imparted by hydrodynamic drag force. The A1 core is protected from force-in...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD029942 | Pride
Mucin Protein stability Hdxms Von willebrand factor Conformational change Glycoprotein Hydrogen deuterium exchange Intrinsically disordered protein 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
ProteomicsA CRISPR/Cas9 engineered Von Willebrand factor deficient endothelial cell model shows alternative trafficking of Weibel-Palade body proteins
Synthesis of the hemostatic protein Von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel-Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are co-stored in WPBs are subject to alternative trafficking routes. In Von Willebr...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013857 | Pride
Von willebrand factor Endothelial cells Protein transport Gene knockout techniques Secretory vesicles 
TranscriptomicsEffect of von Willebrand factor on gene expression in HUVECs
Von Willebrand factor is a paracrine/autocrine regulator of human mesenchymal stem cell adhesion to distressed/apoptotic endothelial cells. This data set examines effect of vWF on gene expression in HUVECs.
ORGANISM(S): Homo sapiens 
2010-11-10 | GSE19816 | GEO
ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
GenomicsA Novel Biological Role for von Willebrand Factor in Linking Primary Hemostasis and Innate Immunity
A Novel Biological Role for von Willebrand Factor in Linking Primary Hemostasis and Innate Immunity
PRJNA844610 | ENA
GenomicsGut microbiota regulate hepatic von Willebrand Factor synthesis and arterial thrombosis via Toll-like receptor-2
Gut microbiota regulate hepatic von Willebrand Factor synthesis and arterial thrombosis via Toll-like receptor-2
PRJEB20546 | ENA
Unknownvon Willebrand disease.
Not available
S-EPMC3832952 | biostudies-literature
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