Sort   by:  
 Page size 
TranscriptomicsTranscriptional profiling of rats treated with VX-765 and Anakinra
Various studies showed a significant production/release of IL-1 beta following status epilepticus (SE) and during epileptogenesis. We studied the role of this cytokine in the epileptogenic process by blocking its production and downstream effects in vivo in a model of acquired epilepsy following SE ...
ORGANISM(S): Rattus norvegicus 
2013-12-10 | E-MTAB-1567 | biostudies-arrayexpress
ProteomicsPhosphoproteomic Analysis Suggests Compensatory Effects in the Piriform Cortex Region of the VX-Exposed Rat
To gain insight into the toxicity induced by VX, a mass spectrometry based phosphoproteomics approach was employed to understand the signaling modulated by VX toxicity in piriform cortex region of the rat brain. We have employed isobaric-based TMT labeling and titanium dioxide- based enrichment str...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-01-07 | PXD001184 | Pride
Vx Phosphoproteomics Signaling 
TranscriptomicsGene expression changes in human cardiomyocytes exposed to VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate)
Organophosphorus compounds induce cardiotoxicity through currently unknown mechanisms, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. We used microarrays to study gene expression changes in human cardiomyocytes after exposure to VX...
ORGANISM(S): Homo sapiens 
2011-10-28 | E-GEOD-33325 | biostudies-arrayexpress
TranscriptomicsGene expression changes in human hepatocytes exposed to VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate)
Organophosphorus compounds induce hepatotoxicity through currently unknown mechanisms, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. We used microarrays to study gene expression changes in human hepatocytes after exposure to VX, a...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-33606 | biostudies-arrayexpress
TranscriptomicsGene expression changes in human neural cells exposed to VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate)
Organophosphorus compounds may induce neurotoxicity through mechanisms other than the cholinergic pathway, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. We used microarrays to study gene expression changes in human neural cells af...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-33109 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in influenza A infected human macrophages treated with VX-787
Analysis of gene expression in macrophages infected with influenza A virus or Mock and treated with the VX-787 to investigate the effects VX-787 have on transcriptional response in human macrophages. Human macrophages were infected with influenza A/WSN/1933(H1N1) or A/Udorn/307/72(H3N2) viruses, or ...
ORGANISM(S): Homo sapiens 
2016-04-03 | E-GEOD-79854 | biostudies-arrayexpress
ProteomicsPlasma Biomarkers for VX exposure in guinea pigs
Biomarker discovery using plasma obtained from exposed guinea pigs (N=6) exposed to VX.
ORGANISM(S): Cavia porcellus (Guinea pig) 
2020-08-03 | PXD017254 | Pride
Vx Cwa Guinea pig Biomarker 
TranscriptomicsmicroRNA (miRNA) expression data from induced pluripotent stem cell (iPSC)-derived neurons exposed to VX
Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-48670 | biostudies-arrayexpress
TranscriptomicsmicroRNA (miRNA) expression data from induced pluripotent stem cell derived (iPSC) derived cardiomyocytes exposed to VX
Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-48470 | biostudies-arrayexpress
ProteomicsPhotoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Cystic fibrosis (CF) pharmacological correctors such as VX-445 are used in combinations as highly effective modulator therapy (HEMT) at CF clinics due to their efficacy in improving Cystic Fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Yet, several side-effects...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060898 | Pride
Elexacaftor Cystic fibrosis (cf) Vu439 Click chemistry Target identification Cystic fibrosis transmembrane conductance regulator (cftr) Off-target Mass spectrometry (ms) Proteomics Diazirine Metabolomics Chemoproteomics Corrector Photoaffinity ligand (pal) Vx-445 Saccharopine dehydrogenase-like oxidoreductase (sccpdh) 
Sort   by:  
 Page size