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TranscriptomicsCyclin D1 Transgenic Mice with Bim-deficient B-cells
Expression analysis from a genetically engineered mouse model of mantle cell lymphoma (MCL) Gene expression was measured in fourteen mice that overexpress cyclin D1 and delete Bim in their B cells and that were stimulated with sheep red blood cells (SRBC) and irradiation (I), pristane (P) or only SR...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-52214 | biostudies-arrayexpress
ProteomicsTargeting MCL-1 Causes DNA Damage and Cell Cycle Arrest Independent from Apoptosis Induction
MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side-effects. MCL-1 biology is complex, extending beyond apoptotic regulation and confounded by its multiple isoforms, domains of un...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036327 | Pride
Cell cycle arrest Cancer Therapeutic window Bcl-2 family Mcl-1 Cell proliferation Apoptosis Dna damage Chemotherapy Affinity enrichment mass spectrometry 
ProteomicsA Triple Action PROTAC for Wild-Type p53 Cancer Therapy
Multiagent chemotherapy remains a cornerstone of cancer treatment but the side effects of each drug component can heighten toxicity and the pharmacologic challenges in achieving simultaneous cellular delivery can reduce efficacy and promote resistance. To address these limitations, we developed a Tr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD060332 | Pride
Bet proteins Cancer Brd4 Taptac Degradation Mdm2/hdm2 Protac Mdmx/mdm4/hdmx Chimera Therapeutic P53 Stapled peptide 
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