Sort   by:  
 Page size 
UnknownThe MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer.
Not available
S-EPMC4999457 | biostudies-literature
UnknownMicroRNA-34a modulates MDM4 expression via a target site in the open reading frame.
Not available
S-EPMC3411609 | biostudies-literature
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsA Triple Action PROTAC for Wild-Type p53 Cancer Therapy
Multiagent chemotherapy remains a cornerstone of cancer treatment but the side effects of each drug component can heighten toxicity and the pharmacologic challenges in achieving simultaneous cellular delivery can reduce efficacy and promote resistance. To address these limitations, we developed a Tr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD060332 | Pride
Bet proteins Cancer Brd4 Taptac Degradation Mdm2/hdm2 Protac Mdmx/mdm4/hdmx Chimera Therapeutic P53 Stapled peptide 
TranscriptomicsCLIP-seq of Trypanosoma brucei cells in procyclic stages to investigate transcriptome wide mapping of MRB8170 and MRB4160
iCLIP-seq experiment to asses the binding of mitochondrially targeted MRB8170 and MRB4160 involved in RNA editing on a genomic scale. Furthermore, to investigate what subsets of maxicircles transcripts (pan-edited, minimally-edited and never-edited) are bound to both the above proteins in vivo.
ORGANISM(S): Trypanosoma brucei TREU927 
2016-08-14 | E-MTAB-4934 | biostudies-arrayexpress
TranscriptomicsGWAS region focused capture-HiC of primary melanocytes from five human donors
Capture-HiC was conducted to map chromatin interactions at all melanoma GWAS identified risk-associated regions across five individual primary human melanocyte cultures. Capture-HiC baits were designed by Arima Genomics (San Diego, CA, 2x tiling, least stringent masking, XTHSBoosting) to obtain an A...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15079 | biostudies-arrayexpress
TranscriptomicsAssay for Transposase-Accessible Chromatin sequencing (ATAC-seq) of primary melanocytes from five human donors
ATAC-seq was conducted to map open chromatin regions in five individual primary human melanocyte cultures. The ATAC libraries were sequenced using paired-end sequencing on an Illumina NovaSeq platform. In total, we sequenced 15 ATAC libraries from these five independent primary melanocyte cultures (...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15048 | biostudies-arrayexpress
GenomicsEGAS00001002309-sc-2020-10-08T12:32:47Z - samples
Background: The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the RB1 gene. However, cases exist where RB1 mutations are undetectable suggesting alternative pathways to malignancy. Methods: We applied comprehensive whole genome sequencing (WGS) a...
EGAD00001006431 | EGA
Sort   by:  
 Page size