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TranscriptomicsGene expression changes associated with the airway wall response to injury
Understanding the way in which the airway heals in response to injury is fundamental to dissecting the mechanisms underlying airway disease pathology. Only limited data is available in relation to in vivo characterisation of the molecular features of repair in the airway. This study sought to charac...
ORGANISM(S): Ovis aries 
2013-05-27 | E-GEOD-37086 | biostudies-arrayexpress
TranscriptomicsA Single Amino-Acid Substitution of RNA Polymerase M-CM-^_ subunit Confers A Novel Class of VISA phenotype on hVISA Strain Mu3
hVISA clinical strain Mu3 spontaneously generates VISA at an extremely high frequency (1x10-6 or greater) within its cell population. The VISA-converted mutant strains generally grow slower than their parent hVISA strain, but they usually form colonies on vancomycin-containing agar plates after 48 h...
ORGANISM(S): Staphylococcus aureus 
2014-03-31 | E-GEOD-50826 | biostudies-arrayexpress
ProteomicsDirect capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis by Cycliphostin & Cyclipostins analogs
Tuberculosis (TB) which is one of the deadliest infectious disease worldwide, is caused by the inhalation of the pathogenic bacteria Mycobacterium tuberculosis. Since many years now, the emergence of multiple (MDR), extensively (XDR) and totally (TDR) drug resistant strains amplifies the incidences ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Bacteria 
2022-09-20 | PXD034921 | Pride
Lc-msms  drug susceptibility  activity based-protein profiling  proteomic analysis  biochemical characterization  3d structure 
TranscriptomicsCytokinin induction of roots and shoots
Arabidopsis Col-0 seedlings grown in liquid culture to growth stage 1.0 were treated with 5 M-5M Benzyladenine and incubated for the indicated time points. Roots and shoots of the seedlings were then harvested separately by taking each individual seedling with a soft forceps at the hypocotyl, dippin...
ORGANISM(S): Arabidopsis thaliana 
2011-06-20 | E-CAGE-111 | biostudies-arrayexpress
TranscriptomicsTissue-enriched expression profiles in Aedes aegypti identify hemocyte-specific transcriptome responses to infection
We present a microarray study of hemocyte-enriched transcriptome in Aedes aegypti. We directed our efforts to critically assess the transcriptomic features distinctive of hemocytes, and discussed our findings in relation to infection-responsive genes and immune-relate gene families. Specifically, ou...
ORGANISM(S): Aedes aegypti 
2012-07-22 | E-GEOD-38744 | biostudies-arrayexpress
TranscriptomicsIdentification of novel potato candidate genes for quantitative resistance to Phytophthora infestans by SuperSAGE transcriptome analysis
To gain novel molecular insights into quantitative late blight resistance, we performed a high-resolution quantitative analysis of gene expression using potato cultivars with contrasting SNP alleles at the StAOS2 locus associated with maturity corrected resistance (MCR). SuperSAGE samples were gener...
ORGANISM(S): Solanum tuberosum 
2013-10-10 | E-GEOD-48071 | biostudies-arrayexpress
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [RNA-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54240 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to aluminum stress in roots of aspen (Populus tremula L.)
Background: Solubilized aluminum (Al) is rhizotoxic and can be present in acid soils at levels that inhibit root growth. Acid soils are found throughout the world and often support forests. However, unlike in herbaceous plants, little is known about the mechanisms by which forest trees respond to an...
ORGANISM(S): Populus tremula 
2010-08-24 | E-GEOD-19297 | biostudies-arrayexpress
TranscriptomicsArchR projects from single-nucleus ATAC-seq datasets across 4 Poeciliid fishes
Characterisation of the chromatin accessibility of cell types in the ovary of livebearing Poeciliid species. Fish were culled by anaesthetic overdose (MS222 or Aquased) followed by decapitation under local animal use regulations, with procedures approved by the local ethics committees at each instit...
ORGANISM(S): Poeciliopsis gracilis 
2026-10-19 | E-MTAB-17776 | biostudies-arrayexpress
TranscriptomicsRNA-seq Analysis of MoRFX1-dependent Genes in Magnaporthe oryzae 70-15
Purpose: The goals of this study are to find out the genes regulated directly or indirectly by the regulatory factor X protein MoRfx1 by RNA-seq in the rice blast fungus Methods: Mycelial mRNAs of the wild type strain 70-15, ΔMorfx1 incubated in H2O at 25˚C for 4 h, in triplicate independently for...
ORGANISM(S): Magnaporthe oryzae 
2016-07-20 | E-GEOD-65296 | biostudies-arrayexpress
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