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ProteomicsTargeting mitophagy in SRSF2 mutant hematologic malignancies
Recurrent Glycogen synthase kinase-3 (GSK-3) phosphorylates multiple splicing factors, including SRSF2, and regulates the splicing of a broad range of mRNAs in human cells. Inhibition of GSK-3 disrupts splicing and promotes cell death in hematopoietic cells with heterozygous mutations in SRSF2 and n...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD043213 | Pride
Mitophagy Chronic myelomonocytic leukemia (cmml) Myelodysplasia Srsf2 Acute myeloid leukemia Splicing Nonsense mediated decay Gsk-3 Pink1 
ProteomicsAAV-mediated transduction of the Ant1 gene restores heart function in the Ant1-/- mouse model of mitochondrial cardiomyopathy
Primary mitochondrial disease (PMD) patients manifesting cardiomyopathy are twice as likely to die as other PMD patients. One PMD with cardiomyopathy is caused by null mutations in the heart-muscle isoform of the adenine nucleotide translocator (ANT1) gene, the severity of the cardiomyopathy being m...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-28 | PXD058090 | Pride
Mitochondria Mouse Ant1 Heart 
UnknownMitochondrial DNA associations with East Asian metabolic syndrome.
Not available
S-EPMC6530988 | biostudies-literature
TranscriptomicsTranscriptomic analysis of human cybrid cell lines harboring increasing levels of the mitochondrial DNA (mtDNA) 3243A>G mutation
Mitochondria generate signals of adaptation that regulate nuclear genes expression via retrograde signaling. But this phenomenon is complexified when qualitatively different mitochondria and mitochondrial DNA (mtDNA) coexist within cells. Although this cellular state of heteroplasmy leads to diver...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-56158 | biostudies-arrayexpress
ProteomicsHepatocyte mitochondrial NAD+ content is limiting for liver regeneration
Supplemental NAD+ precursors show metabolic and functional benefits in rodent models of disease and are being explored as potential therapeutics in human studies. However, the wide range of processes that involve NAD+ in every cell and subcellular compartment make it difficult to narrow down mechani...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-08-15 | MSV000098839 | MassIVE
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
UnknownPredictors for the development of referral-warranted retinopathy of prematurity in the telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study.
Not available
S-EPMC4416963 | biostudies-literature
UnknownValidity of a telemedicine system for the evaluation of acute-phase retinopathy of prematurity.
Not available
S-EPMC4861044 | biostudies-literature
UnknownValidated System for Centralized Grading of Retinopathy of Prematurity: Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study.
Not available
S-EPMC4910817 | biostudies-literature
UnknownTelemedicine approaches to evaluating acute-phase retinopathy of prematurity: study design.
Not available
S-EPMC4861056 | biostudies-literature
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