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TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
TranscriptomicsAnalysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17344 | biostudies-arrayexpress
TranscriptomicsHuman SV80 Cells: Control vs. Caspase-8 knock down
Excessive responses to pattern-recognition receptors are prevented by regulatory mechanisms that affect the amounts, conformation, and associative properties of their signaling proteins. We report that signaling by the ribonucleic acid sensor RIG-I is restricted, in addition, by caspase-mediated cle...
ORGANISM(S): Homo sapiens 
2011-02-07 | E-GEOD-23363 | biostudies-arrayexpress
ProteomicsPregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
Pregnancy places a metabolic burden on the body including the liver, which is responsible for ensuring adequate nutrition for the maternal and fetal systems. To gain a better understanding of liver adaptation, this study investigates metabolic shifts occurring in livers of pregnant rats. Metabolic c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-22 | PXD050758 | Pride
Pregnancy Metabolic Structural liver changes 
ProteomicsOn the relationship between metabolic capacities and in vivo viscoelastic properties of the liver
The liver is the central metabolic organ. It constantly adapts its metabolic capacity to current physiological requirements. However, the relationship between tissue structure and hepatic function is incompletely understood; this results in a lack of diagnostic markers in medical imaging that can pr...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2022-12-21 | PXD036659 | Pride
Tomoelastography Pet Proteomics Hepatic function model Reserve capacity Viscoelasticity Liver metabolism Magnetic resonance elastography Stiffness Mre 
ProteomicsMetabolomics Integration with Gene expression profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC large B cell Lymphoma
Drug resistant acute B-cell lymphoma cells were analyzed via LC-MS metabolomics to identify deregulated metabolic pathways that are associated with drug resistance.
ORGANISM(S): Human 
2021-03-16 | MSV000087059 | MassIVE
UnknownPharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis.
Not available
S-EPMC5763501 | biostudies-literature
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