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ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsThe antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy
Direct analysis of HLA-presented antigens by mass spectrometry provides a comprehensive view on the antigenic landscape of different tissues/malignancies and enables the identification of novel, pathophysiologically relevant T-cell epitopes. Here, we present a systematic and comparative study of the...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD035324 | Pride
Human leukocyte antigens T-lymphocytes Mass spectrometry Immunotherapy Ligands Peptides Antigens Multiple myeloma 
ProteomicsThe resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex
The T-cell receptor (TCR) initiates T-lymphocyte activation, but the mechanism of TCR activation remains uncertain. Here, we present cryogenic electron microscopy structures for the unliganded and human leukocyte antigen (HLA)-bound human TCR–CD3 complex in nanodiscs that provide a native-like lipid...
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD070648 | Pride
Tcr2 Disulfide bridge Membrane 
ProteomicsHCMV deletion models enable the identification of physiologically relevant T-cell epitopes
In healthy individuals, immune control of persistent human cytomegalovirus (HCMV) infection is effectively mediated by virus-specific CD4+ and CD8+ T cells. However, identification of the repertoire of T-cell specificities for HCMV is hampered by the immense protein coding capacity of this betaherpe...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2019-11-20 | PXD013120 | Pride
Hla Hla ligandomics T-cell epitopes Human cytomegalovirus Immunoevasin deletion Immunotherapy Mhc affinity prediction 
ProteomicsUnveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling
The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ T cells. In addition to canonical viral protein coding sequences (CDSs), we identify 98 alternative open read...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD043984 | Pride
Hiv-1 Ribosome profiling Immunopeptidome 
ProteomicsThe Immunopeptidomic Landscape of Ependymomas provide actionable antigens for T cell-based immunotherapy
Ependymoma (EPN) are primary tumors of the nervous system. Due to their growth pattern, most ependymoma can be managed with neurosurgical resection alone. A substantial proportion of these tumors recurs or display infiltrative growth pattern, however. Therapeutic options after neurosurgical resectio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052448 | Pride
Peptide vaccine Hla ligands Mass spectrometry Cancer vaccination Neuroepithelial tumor Immunotherapy 
ProteomicsThe HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy
Anti-leukemia immunity plays an important role for disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Antigen-specific immunotherapy holds promise to strengthen immune control in CML, but requires the identification of CML-associated ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010450 | Pride
Mass spectrometry Chronic myeloid leukemia Immunopeptidome 
ProteomicsIncreased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity
HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly inc...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD029567 | Pride
Covid-19 Immunopeptidome Soluble hla 
Proteomics Autoreactive T Cells Recognize Unique MBP Peptides Naturally Presented by EBV-Infected B Cells and Multiple Sclerosis Brain Tissue
Epstein-Barr virus (EBV) is involved in causing and probably also perpetuating multiple sclerosis (MS). Among several mechanisms, how EBV may contribute, are transcriptome alterations including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we foun...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD068488 | Pride
Multiple sclerosis Brain Ebv Immunopeptidomics B cells T cells 
UnknownSARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function.
Not available
S-EPMC8646365 | biostudies-literature
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