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ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
GenomicsIntegrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation [HMST-Seq]
5-methylcytosine (5-mC) can be oxidized to 5-hydroxymethylcytosine (5-hmC). Genome-wide profiling of 5-hmC thus far indicated 5-hmC may not only be an intermediate form of DNA demethylation but could also constitute an epigenetic mark per se. We describe a cost-effective and selective method to dete...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-41069 | biostudies-arrayexpress
MetabolomicsHealth outcomes of fruit juice and fruity beverage: a comparative analysis of gut microbiota and metabolomics in rats (Lipidomics assay)

BACKGROUND: Diet is foods and drinks regularly consumed, and its regulation is complicated. It is necessary to obtain a practical understanding of which foods and drinks contribute to health and well-being and which are insalubrious. Clear evidence shows that a high intake of fru...

2022-08-24 | MTBLS4108 | MetaboLights
ProteomicsCoordination of cyanobacterial nitrate assimilation and photosynthesis by a novel PsbO-interacting protein PirN
Nitrogen assimilation relies on photosynthetically-produced energy and reducing equivalents. Here, we identify a small protein, PsbO-interacting regulator of nitrate assimilation (PirN), as a key coordinator of photosynthesis and nitrate assimilation in Synechocystis sp. PCC 6803 (Synechocystis). Pi...
ORGANISM(S): Synechocystis sp. PCC 6803 substr. GT-T 
2026-06-08 | PXD066894 | Pride
Cyanobacteria Photosynthesis Psbo Nitrate assimilation Pirn 
UnknownZfp281 and Zfp148 control CD4<sup>+</sup> T cell thymic development and T<sub>H</sub>2 functions.
Not available
S-EPMC12291171 | biostudies-literature
UnknownPD-1<sup>IR2</sup> promotes tumor evasion via deregulating CD8<sup>+</sup> T cell function.
Not available
S-EPMC11887316 | biostudies-literature
UnknownCharacterizing HLA-A2-restricted CD8<sup>+</sup> T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.
Not available
S-EPMC11958996 | biostudies-literature
UnknownTwo chemotherapeutic agents expand stem-like CD62L<sup>+</sup>CD8<sup>+</sup> T cells in antitumor immune responses.
Not available
S-EPMC11996895 | biostudies-literature
UnknownPreparation and application of fluorescent monoclonal antibodies recognizing goat CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells.
Not available
S-EPMC11078799 | biostudies-literature
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