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ProteomicsThe E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes
we identify the ubiquitnation sites of BST2 and used quantitative proteomic analysis to compare protein abundance between WT MA-C cells and those that have received FBXL18-specific siRNAs
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD058432 | Pride
Bst2 ubiquitination，fbxl18 proteomics 
UnknownComparative profiling of 72 quinoa varieties reveals superior nutritional quality, bio-active petrochemicals, and sensory acceptability for functional leafy vegetable applications.
Not available
S-EPMC12801603 | biostudies-literature
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
ProteomicsHuman intestine LC-MSMS - Transcriptional and proteomic analysis revealed a synergistic effect of aflatoxin M1 and ochratoxin A mycotoxins on intestinal epithelial integrity of differentiated human Caco-2 cells
Aflatoxin M1 (AFM1) is a common mycotoxin in dairy milk and it is typically concurrently present with other mycotoxins that may represent a threat for food safety. However, knowledge on how AFM1, alone or in combination with other mycotoxins may affect human intestinal epithelial integrity remain to...
ORGANISM(S): Homo sapiens (Human) 
2018-08-08 | PXD009437 | Pride
Human Intestinal epithelial cells Lc-msms 
ProteomicsIdentification of indisulam-mediated DCAF15 interacting proteins by TurboID and shotgun proteomics
In this project, we used proximity labeling with TurboID to identify proteins that interact with DCAF15 in the presence of indisulam in a gastric cancer AGS cell line.
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD024168 | Pride
Human Ags Turboid Dcaf15 Orbitrap fusion lumos Lc-ms/ms 
UnknownRandomized controlled trial of icodextrin versus glucose containing peritoneal dialysis fluid.
Not available
S-EPMC2774964 | biostudies-literature
ProteomicsLactylation-stabilized NOL6 promotes colorectal cancer progression via recruiting STAMBP to deubiquitinate YY1 and upregulate MYC transcription
Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of Spindle and Nucleolar Protein 6 (NOL6) in CRC progression. In this study, we found NOL6 was significantly overexpressed in CRC tissues, ...
ORGANISM(S): Homo Sapiens 
PXD069802 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsProteomics of exosomes derived from cisplatin-induced dormant A549 cells
Lung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy kills most cancer cells, however, the residual cells enter into dormant state. The dormant cancer cells can be reactivated under specific circumstances. Tumor-derived exosomes are the main mediators of tumorigenesis. W...
ORGANISM(S): Homo Sapiens 
2022-10-17 | PXD037475 |
ProteomicsHippocampal subfields proteome analysis and comparation in Alzheimer’s disease providing new sight on glia function
The hippocampus and entorhinal cortex are the earliest areas affected by AD pathology, which are related to early memory loss in patients. The hippocampus subfields are heterogeneous, with different order and degree affect by AD pathology. Studying the molecular changes may explain the difference, a...
ORGANISM(S): Homo Sapiens 
2021-07-16 | PXD027380 |
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