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ProteomicsHaemonchus contortus secretome LC-MS/MS
The excretory-secretory (ES) proteins are the molecules that actively or passively released by parasite at the parasite-host interface to maintain a physiological and immunological relationship with the host. In the present study, we characterised the excretory-secretory products from the short-term...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2019-06-18 | PXD012503 | Pride
Haemonchus contortus Lc-ms/ms Parasitic nematode Secretome 
ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
UnknownLandscape topography structures the soil microbiome in arctic polygonal tundra.
Not available
S-EPMC5823929 | biostudies-literature
ProteomicsIdentifying proteins altered during Methyl methanesulfonate treatment
Humans are exposed to a wide range of exogenous and endogenous alkylating agents, including agents frequently used as cytostatic drugs in cancer treatment (Drablos, Feyzi et al. 2004). Alkylating agents are mutagenic and cytotoxic and the major body of research has focused on their effects upon DNA....
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD003549 | Pride
Proteomics Methyl methanesulfonate Prbitrap Silac Label-free Dna damage Quantification 
ProteomicsProteomics analysis of human islets treated with IL-1b and IFN-g
Human islets were treated with IL-1b and IFN-g for 24h, digested with trypsin, multiplexed with TMT-10, fractionated by high pH reverse-phase chromatography and analyzed by tandem LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-10-25 | PXD009131 | Pride
Proteomics Tmt-10 Cytokines Human islets Type 1 diabetes Cell death 
ProteomicsProteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons
Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we u...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD037526 | Pride
Lc-ms/ms Huntington's disease Mitochondria Neurodegeneration 
UnknownChronic exposure to complex metal oxide nanoparticles elicits rapid resistance in Shewanella oneidensis MR-1.
Not available
S-EPMC6993611 | biostudies-literature
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
ProteomicsAngiogenic patterning by STEEL, an endothelial-enriched long noncoding RNAAngiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA
Endothelial cell (EC)-enriched protein coding genes, such as endothelial nitric oxide synthase (eNOS), define quintessential EC-specific physiologic functions. It is not clear whether long noncoding RNAs (lncRNAs) also define cardiovascular cell-type specific phenotypes, especially in the vascular e...
ORGANISM(S): Homo sapiens (Human) 
2018-02-28 | PXD008581 | Pride
Endothelium Gene regulations Long noncoding rna 
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