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ProteomicsMass Spectrum-based Identification of direct-binding proteins of TAIII-probe
This experiment utilizes a technology platform based on the Ultimate 3000 nano ultra-high-performance liquid chromatography coupled with the Q Exactive Plus high-resolution mass spectrometer, combined with database search software, to perform qualitative (or relative quantitative) analysis of protei...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD060766 | Pride
ProteomicsQuantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy
Autophagy is an intracellular degradation mechanism in response to nutrient starvation. Via autophagy, some non-essential cellular constituents are degraded in a lysosome-dependent manner to generate biomolecules that can be utilized for maintaining the metabolic homeostasis. Although it is known th...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD003546 | Pride
Autophagy Boncat Proteomics Aha De novo protein synthesis Itraq 
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
ProteomicsHeme-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum
Plasmodium falciparum, the most pathogenic human malaria parasite, infects millions of human beings and causes a serious public health threat. Currently, the most potent anti-malarial drugs are artemisinin and its derivatives1,2. Artemisinin is a sesquiterpene lactone with an endoperoxide bridge3. T...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2015-12-17 | PXD002611 | Pride
Mechanism of action Target Artemisinin Chemical proteomics 
UnknownNeoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Not available
S-EPMC6145832 | biostudies-literature
ProteomicsComparative proteomic and phosphorylated proteomic analyses revealed differences in sperm motility in Mediterranean buffalo
In this study, Mediterranean buffalo semen was used as experimental material, and quantitative proteomics and phosphorylation modification techniques were used to analyze the proteins and phosphorylation sites of Mediterranean buffalo sperm with different motility, so as to further study the protein...
ORGANISM(S): Bos Taurus 
2024-10-22 | PXD055618 |
GenomicsH2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation
Chromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear. We show that H2A.Z is highly enriched at promoters and enhancers and is required for both efficient self-renewa...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-34483 | biostudies-arrayexpress
UnknownElectronic symptom monitoring after lung cancer surgery: establishing a core set of patient-reported outcomes for surgical oncology care in a longitudinal cohort study.
Not available
S-EPMC11486944 | biostudies-literature
Proteomicsyagwall_712rpt
enrichment for Halobacterium cell wall proteins; 700-1200 m/z; Goo et al., unpublished data.
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000225 | PeptideAtlas
ProteomicsProteome profiling of colorectal cancer-infiltrating T cells to screen key regulators of CRC progression.
Using a tandem mass tag (TMT)-based quantitative proteomic study, we described the protein expression pattern of colorectal cancer-infiltrating T cells, revealed T cell dysfunctions in CRC, screened key regulator of CRC progression.
ORGANISM(S): Homo Sapiens 
2023-04-06 | PXD041366 |
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