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TranscriptomicsInsights into responses of human astrocytes to H5N1 infection by transcriptional analysis
Increasing evidence demonstrates influenza virus can not only affect the respiratory system, but also infect CNS and lead to CNS disorder and encephalopathy and encephalitis. Astrocytes are the most abundant cells in the CNS, which are capable of producing cytokines and neurotrophic factors and are ...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66597 | biostudies-arrayexpress
ProteomicsCross-Link of inactive PhK and GP
Phosphorylase kinase (PhK) phosphorylates GP to initiate glycogenolysis. To gain insights into the mechanism of PhK catalyzing GP phosphorylation, we have tried a variety of methods to obtain the hPhK-GP complex, but none of them were successful. Eventually, we decided to employ XL-MS to investigate...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059356 | Pride
Phk Gp Xl-ms 
ProteomicsConfirmation of the phosphorylation sites of human PhK
The activity of PhK is regulated by phosphorylation, and we utilized single-particle cryo-electron microscopy to solve the high-resolution structures of human PhK under phosphorylation and calcium ion activation. To gain a deeper insight into the phosphorylation sites following PKA treatment, we emp...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059345 | Pride
Phosphorylation sites，phk 
ProteomicsCross-Link of active PhK and GP
Phosphorylase kinase (PhK) phosphorylates GP to initiate glycogenolysis. To gain insights into the mechanism of PhK catalyzing GP phosphorylation, we have tried a variety of methods to obtain the hPhK-GP complex, but none of them were successful. Eventually, we decided to employ XL-MS to investigate...
ORGANISM(S): Hordeum vulgare (Barley) 
2025-05-07 | PXD059369 | Pride
Phk Active state Gp Xl-ms 
ProteomicsProteomic stratification of prognosis and treatment options for small cell lung cancer
We analyzed surgically resected formalin-fixed, paraffin-embedded (FFPE) SCLC samples by proteomic profiling and stratified SCLC into three subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses.
ORGANISM(S): Homo Sapiens 
2025-05-27 | PXD064316 |
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