Sort   by:  
 Page size 
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
ProteomicsHost-defence peptides caerin 1.1 and 1.9 stimulate TNF-alpha-dependent apoptosis in human cervical cancer HeLa cells
TNFα pathway has been recognised as one of the most important signalling pathways characterising molecules with anti-cancer activity, due to it closely relates to cell survival as well as apoptosis. Isolated from the glandular secretion of Australian tree frogs, the genus Litoria, host-defence caeri...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD015975 | Pride
Proteomics Hela cell Tmt labelling Tnfα signalling pathway Caerin peptide Apoptosis Confocal microscopy Western blot 
ProteomicsA proteomic investigation of sporophyte and gametophyte in the red seaweed Asparagopsis
The red seaweed, Asparagopsis taxiformis, is a promising ruminant feed-additive with significant anti-methanogenic properties, which could provide a global solution to climate-change. Emerging genomics in this species has provided a strong foundation for in-depth molecular investigations, including ...
ORGANISM(S): Asparagopsis taxiformis 
2023-01-26 | PXD035669 | Pride
Lc-ms/ms Sporophyte Proteomics Asparagopsis taxiformis (l6) Gametophyte 
ProteomicsProteomic characterisation of byssus components in the pearl oyster, Pinctada maxima
Many bivalve species produce groups of strong proteinaceous byssal threads to rigidly attach to underwater substrates. Fibres like these have potential applications as biomedical materials due to their unique mechanical characteristics. The byssus and byssal thread producing glands of Pinctada maxim...
ORGANISM(S): Pinctada maxima 
2022-07-31 | PXD028273 | Pride
Proteomics Nacre Pinctada maxima Transcriptomics Byssal threads Byssus 
ProteomicsA novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its rol...
ORGANISM(S): Saccostrea glomerata 
2023-01-27 | PXD039155 | Pride
Metabolism Transcriptome Teneurin Heart Tcap Heart rate Oysters Stress 
ProteomicsExcretory-secretory proteins released by Schistosoma mansoni-resistant, susceptible and naïve Biomphalaria glabrata
Schistosomiasis is one of the most socioeconomically harmful neglected tropical diseases in the world. It occurs following infection from parasites of the Schistosoma genus, such as Schistosoma mansoni, which must transition within a molluscan and mammalian host to survive. Previous chemical analyse...
ORGANISM(S): Biomphalaria glabrata 
2019-09-26 | PXD015129 | Pride
Schistosoma mansoni Proteomics Excretory-secretory proteins Biomphalaria glabrata Miracidia Ppi 
ProteomicsIdentification of neuropeptides in the Crown-of-Thorns Starfish, Acanthaster planci
The Crown-of-thorns starfish (COTS) Acanthaster planci feeds on hard corals and its outbreaks are a major cause of destruction of coral communities on the Australian Great Barrier Reef. Whilst population booms and the social behaviour of COTS have been well studied, little is known about the neural ...
ORGANISM(S): Acanthaster planci 
2018-03-01 | PXD005837 | Pride
Neurotransmitter Crown-of-thorns starfish Neuropeptide Acanthaster planci 
ProteomicsProteomic comparison of Biomphalaria glabrata excretory-secretory proteins at different time-points of Schistosoma mansoni infection
Schistosomiasis, caused by infection with Schistosoma trematode parasites, is one of the deadliest neglected tropical diseases in the world. The Schistosoma lifecycle involves the miracidia infection of an intermediate molluscan host, such as Biomphalaria glabrata. Dispersing B. glabrata attractant ...
ORGANISM(S): Biomphalaria glabrata Schistosoma mansoni (Blood fluke) 
2022-10-03 | PXD031989 | Pride
Biomphalaria glabrata Excretory-secretory proteins Schistosoma mansoni Lc-ms/ms 
ProteomicsQuantitative proteomic analysis of tumour tissues isolated from early and late stage human cervical cancer patients
Human papillomavirus (HPV) infection related malignancy remains a severe public health problem worldwide, although HPV prophylactic vaccine has been introduced 15 years ago . HPV-associated cancers comprise 29.1% of all 2.2 million infection-related cancers, including nearly 100% of cervical cancers...
ORGANISM(S): Homo sapiens (Human) 
2023-01-26 | PXD029103 | Pride
Itraq8plex Cervical cancer Lc-ms/ms 
Sort   by:  
 Page size