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ProteomicsMining novel gene targets for improving tolerance to furfural and acetic acid in Yarrowia lipolytica using whole-genome clustered regularly interspaced short palindromic repeats interference library
In this study, a whole-genome CRISPRi library was developed in Y. lipolytica and applied for enforcing the tolerance to furfural and acetic acid. Several novel gene targets were discovered through NGS before and after screening. And to analyze the tolerance mechanism caused by transcriptional repres...
ORGANISM(S): Yarrowia Lipolytica 
2024-03-31 | PXD051116 |
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
UnknownACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3-5: A Network Meta-Analysis of Randomised Clinical Trials.
Not available
S-EPMC7242277 | biostudies-literature
ProteomicsCharacterization of lysine acetylome in mice subjected to chronic intermittent hypoxia
Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in ...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049226 |
ProteomicsChanges in the hippocampal proteome of chronic intermittent hypoxia mice
Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hip...
ORGANISM(S): Mus Musculus 
2024-02-07 | PXD049225 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
ProteomicsGenome-wide targets identification for high-titer production of free fatty acids in Escherichia coli
We employed omics analyses to identify potential targets in multiple cellular processes, enabling systematical discovery of beneficial chromosomal gene targets that can be engineered to optimize free fatty acids (FFAs) production in Escherichia coli.
ORGANISM(S): Escherichia Coli 
PXD017890 |
ProteomicsGenome-scale CRISPRi screen identifies pcnB repression conferring overproduction of free fatty acids in Escherichia coli
In this study, we carried out genome-scale CRISPRi modulation combining fluorescence-activated cell sorting (FACS) and next-generation sequencing (NGS) to identify genetic determinants for FFAs overproduction in Escherichia coli. The pcnBi (AP) strain that repressed the expression of pcnB produced 2...
ORGANISM(S): Escherichia Coli 
PXD052390 |
ProteomicsNoninvasive urinary protein signatures combined clinical information associated with Microvascular Invasion Risk in patients with HCC
Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). There is an urgent need for reliable preoperative prediction of MVI indicators in order to formulate a reasonable treatment plan for patients.
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037409 |
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