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UnknownPhylloquinone Attenuates Oxygen-Glucose Deprivation-induced Neuronal Injury by Inhibiting Ferroptosis via the xCT/GPX4 Pathway.
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S-EPMC12657559 | biostudies-literature
ProteomicsPhosphoproteomics reveal that phosphorylation of MTDH by CDK5 inhibits protein synthesis in microglia
Our findings identified 335 phosphorylation sites on 234 proteins as potential CDK5 substrates in microglia based on the reported sequence motif
ORGANISM(S): Mus Musculus 
2024-03-08 | PXD050465 |
ProteomicsProteomic Sequencing of Blood Across Different Growth Stages of Deer Antler
Aim to detect the differential protein expression of plasma samples collected in different stage using DIA quantitative proteome technology.
ORGANISM(S): Cervus Nippon 
PXD052882 |
ProteomicsUnveiling EMC6 as a Novel Pathogenic Determinant in hepatocellular carcinoma: Orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13
The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of ...
ORGANISM(S): Mus Musculus 
PXD067920 |
ProteomicsThe LC-MS/MS data of EVs derived from Talaromyces marneffei
Our experiment showed that the immunostimulatory effect of EVs derived from Talaromyces marneffei(TM) was significantly weaken with protease pretreatment, but not in pretreatment with dsDNA and RNase A hydrolase. To further investigate its protein composition, EVs derived from TM were further analyz...
ORGANISM(S): Talaromyces Marneffei 
2020-10-26 | PXD022162 |
ProteomicsDe novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defense
De novo pyrimidine biosynthesis is achieved by cytosolic enzymes, CAD and UMPS, and mitochondrial DHODH. However, how these enzymes are orchestrated remains enigmatical. Here, we show that cytosolic aspartate-producing GOT1 clusters with CAD and UMPS. This cytosolic cluster then connects with DHODH,...
ORGANISM(S): Homo Sapiens 
2023-03-22 | PXD041017 |
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, we found that R236 methylation of PHGDH promotes its activity and stimulates serine synthesis in hepatocellular carcinoma.
ORGANISM(S): Homo Sapiens 
2022-07-28 | PXD035061 |
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and HCC Growth
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme in serine biosynthesis pathway. Here, we analyzed immunoprecipitated PHGDH from human HEK293T cells by liquid ch...
ORGANISM(S): Homo Sapiens 
2022-07-29 | PXD035287 |
Proteomicsproteome sequencing of Triticum aestivum L
The 15 DAP and 20 DAP endosperm samples from WT and lgp1 seeds were used for tandem mass tag (TMT) proteasome analysis. Three biological replicates were used for each genotype
ORGANISM(S): Triticum Aestivum 
PXD027683 |
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
PXD064867 |
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