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ProteomicsMolecular biomarkers of neovascular age-related macular degeneration with incomplete response to anti-vascular endothelial growth factor treatment
The standard treatment for neovascular age-related macular degeneration (nAMD) consists of intravitreal anti-vascular endothelial growth factors (VEGF). However, for some patients, even maximal anti-VEGF treatment does notentirely suppress exudative activity. The goal of this study was to identify m...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022471 | Pride
Human Age-related macular degeneration Orbitrap fusion 
ProteomicsShotgun ecotoxicoproteomics of Daphnia pulex: biochemical effects of the anticancer drug tamoxifen
Among pollutants released into the environment by human activities, residues of pharmaceutical agents have been identified worldwide, and are an increasing matter of concern because of their potential impact on ecosystems. Because micro-crustaceans, such as daphnids, are sensitive to chemicals and a...
ORGANISM(S): Daphnia pulex (Water flea) 
2014-10-31 | PXD001257 | Pride
Tamoxifen Daphnia pulex Ecotoxiproteomics Lc-ms/ms 
ProteomicsEssential role of Cp190 in physical and regulatory boundary formation in Drosophila
Animal genomes fold into contact domains defined by enhanced internal contact frequencies with debated functions in establishing independent gene regulatory domains. A large fraction of contact domains in mammals are formed by stalling of chromosomal loop-extruding cohesin by CTCF at domain boundari...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-30 | PXD027795 | Pride
Genome architecture Development Drosophila 
ProteomicsMolecular evolution of juvenile hormone esterase-like proteins in a socially exchanged fluid
Socially exchanged fluids, such as seminal fluid and milk, are a direct means through which an organism can influence conspecifics. When orally feeding larval offspring via trophallaxis, workers of the carpenter ant Camponotus floridanus were recently shown to transfer Juvenile Hormone III (JH), a k...
ORGANISM(S): Camponotus floridanus 
2018-12-14 | PXD009982 | Pride
Ants Larva Camponotus floridanus 
ProteomicsPhosphorylation of OSBL8 protein in interphase vs mitotic human cells
Phosphorylation of OSBL8 human protein was compared in interphase vs mitotic Hela cells with a new software developed in-house, Msviz, a graphical software tool developed for in-depth manual validation and quantitation of post-translational modifications.
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD006254 | Pride
Osbl8 Tandem mass spectrometry Human Phosphorylation Qexactive 
ProteomicsSocial exchange of chemical cues, growth proteins and hormones through trophallaxis
Social insects frequently engage in oral fluid exchange – trophallaxis – between adults, and between adults and larvae. Although trophallaxis is normally considered a simple food-sharing mechanism, we hypothesized that endogenous components of this fluid might underlie a novel means of chemical comm...
ORGANISM(S): Solenopsis invicta Camponotus fellah Camponotus floridanus Apis mellifera (Honeybee) 
2016-12-12 | PXD004825 | Pride
Trophallactic fluid Social insects Ants Camponotus floridanus 
ProteomicsFragmentation of mitochondrial mt-tRNA-LeuTAA provides a regulator of metabolic physiology
In this study, we discovered cytosolic and mitochondrial fragments resulting from tRNA and mt-tRNA cleavage, which may act as new regulators of cellular and metabolic functions. We selected the mt-tRF-LeuTAA fragment derived from a tRNA encoded by the mitochondrial genome for further investigation, ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046117 | Pride
Mitochondrial metabolism Trna-derived fragment Insulin secretion Insulin sensitivity Mitochondrial trna 
ProteomicsIntramolecular synergism and proteolytic control of bacteriophage endolysin PlySK1249
Endolysins are peptidoglycan hydrolases produced at the end of the bacteriophage (phage) replication cycle to lyse the host cell. Gram-positive phages endolysins come in a variety of multi-modular forms that combine different catalytic domains and may have evolved to adapt to their bacterial hosts. ...
ORGANISM(S): Streptococcus agalactiae FSL S3-026 Streptococcus dysgalactiae subsp. equisimilis SK1249 
2021-04-15 | PXD024020 | Pride
Endolysin Proteolysis Bacteriophage Lc-ms/ms 
ProteomicsNuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD042059 | Pride
Human Cancer-associated fibroblasts Androgen receptor 
ProteomicsContrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
The conserved phosphoprotein MAF1 is the main known direct repressor of RNA polymerase III (Pol III). MAF1 is phosphorylated and inactivated by the nutrient-sensing TORC1 kinase, making MAF1 a nutrient effector for Pol III transcription. MAF1 has been associated with lipid metabolism in D. melanogas...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD040086 | Pride
Rna polymerase iii Transcription repressor Maf1 Hepatocyte Mouse Metabolic regulation 
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