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UnknownDe novo transcriptome and phytochemical analyses reveal differentially expressed genes and characteristic secondary metabolites in the original oolong tea (Camellia sinensis) cultivar 'Tieguanyin' compared with cultivar 'Benshan'.
Not available
S-EPMC6446291 | biostudies-literature
ProteomicsAn integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways
An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD059109 | Pride
Multiomics Metalloproteinase Proteotranscriptomics Integration Adam9 Target identification 
TranscriptomicsmiRNA expression profiles of peripheral monocytes and glioblastoma-infiltrating macrophages
MicroRNAs (miRNAs) are non-coding molecules involved in post-transcriptional gene regulation that have been shown to modulate tumor cell proliferation and apoptosis and to act as oncogenes or tumor-suppressor genes. Although miRNAs have been linked to tumor progression, the connection between tumor-...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-51332 | biostudies-arrayexpress
UnknownIdentification of target genes of Astragalus mongholicus and Saposhnikovia divaricata extracts in human synoviocytes for potential osteoarthritis treatment.
Not available
S-EPMC12506284 | biostudies-literature
TranscriptomicsExpression data of mouse hematopoietic cells, Nr4a1/3 wild type and double mutant
We investigate the cellular and molecular mechanisms of tumor suppression by NR4A1 and NR4A3, and show a cell intrinsic essential function in maintenance of hematopoietic stem cell (HSC) homeostasis. In the absence of Nr4a1/3, HSC lost quiescence, became highly proliferative leukemia-stem cell (LSC)...
ORGANISM(S): Mus musculus 
2013-12-30 | E-GEOD-31042 | biostudies-arrayexpress
ProteomicsIdentification of Novel Biomolecular Characteristics and Bioinformatic Analyses of the Anterior Cingulate Cortex in Morphine-Dependent Mice via Proteomic Profiling
Impaired function of the anterior cingulate cortex (ACC) is widely recognized as a critical factor in drug dependence. This study aimed to investigate protein alterations in the ACC of morphine-dependent mice using 4D label-free quantitative proteomics. Procrustes analysis and Pearson correlation an...
ORGANISM(S): Mus Musculus 
2025-12-05 | PXD071619 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsAmelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-06-15 | PXD053163 |
ProteomicsArrestin engagement of the metabotropic glutamate receptor mGlu5
Phosphorylation sites identified at the C-terminus of mGlu5 by mass spectrometry analysis
ORGANISM(S): Homo Sapiens 
2026-04-01 | PXD076479 |
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
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