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ProteomicsAn integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways
An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD059109 | Pride
Multiomics Metalloproteinase Proteotranscriptomics Integration Adam9 Target identification 
ProteomicsNematode gene annotation by machine learning assisted proteotranscriptomics enables proteome-wide evolutionary analysis
Nematodes encompass over 24,000 described species, which were discovered in almost every ecological habitat, and make up over 80% of metazoan taxonomic diversity in soils. The last common ancestor of nematodes is believed to date back to around 650–750 million years, generating a large and phylogene...
ORGANISM(S): Caenorhabditis elegans 
2022-11-12 | PXD034107 | Pride
Lc-ms/ms  proteotranscriptomics 
UnknownProteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line.
Not available
S-EPMC7541253 | biostudies-literature
UnknownNematode gene annotation by machine-learning-assisted proteotranscriptomics enables proteome-wide evolutionary analysis.
Not available
S-EPMC9977148 | biostudies-literature
ProteomicsProteotranscriptomics of the most popular hoast sea anemone Entacmaea quadricolor reveals not all toxin genes expressed are recruited into its venom arsenal
While the unique symbiotic relationship between anemonefish and sea anemones is iconic, it is still not fully understood how anemonefish withstand and thrive within this venomous host environment. In this study we used a proteotranscriptomics approach to elucidate the proteinaceous toxin repertoire ...
ORGANISM(S): Entacmaea quadricolor 
2024-01-24 | PXD048736 | Pride
Sea anemone Toxin Proteotranscriptomics Venomics 
UnknownSIMD: Synergistic integration mutualistic platform based on single-cell and proteotranscriptomics for drug repositioning.
Not available
S-EPMC12779986 | biostudies-literature
Genomics
Proteotranscriptomics assisted gene annotation of Bombyx mori
PRJNA554660 | ENA
ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
GenomicsAn Integrated Single-Cell and Spatial Proteotranscriptomics Atlas of Fibroblast-Driven Immunoregulation within the Human Adult Oral Cavity
An Integrated Single-Cell and Spatial Proteotranscriptomics Atlas of Fibroblast-Driven Immunoregulation within the Human Adult Oral Cavity
PRJNA1406282 | ENA
ProteomicsAnalysis of Human Breast Tumors by Integrated Proteotranscriptomics
We generated large-scale proteome data for 65 human breast tumors and 53 paired adjacent non-cancerous tissue and performed an integrated proteotranscriptomic characterization. To our best knowledge, the study is one of the largest quantitative proteomic study of human breast tissues, including the ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-04 | PXD005692 | Pride
Breast cancer proteomics 
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