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MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
ProteomicsProteomics and metabolomics reveal changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on a engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treatin...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD004954 | Pride
Metabolism Shmt2 Sodium benzoate Quantitative proteomics Interactome Lc-ms/ms 
UnknownSafe and Effective Delivery of mRNA Using Modified PEI-Based Lipopolymers.
Not available
S-EPMC9967631 | biostudies-literature
ProteomicsCancer proteome and metabolite changes linked to SHMT2
To screen for proximate and interacting proteins of SHMT2 in HeLa cells, the BioID method was employed, which consists of biotinylation of proteins in the vicinity of FlagBirAR118G –SHMT2 followed by streptavidin-based affinity capture and mass spectrometry identification. Experimental procedures we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD004629 | Pride
Streptavidin Shmt2 Ms Bioid 
UnknownMMV-db: vaccinomics and RNA-based therapeutics database for infectious hemorrhagic fever-causing mammarenaviruses.
Not available
S-EPMC8533362 | biostudies-literature
UnknownIntegrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age.
Not available
S-EPMC11785523 | biostudies-literature
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
UnknownCRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions.
Not available
S-EPMC11028344 | biostudies-literature
UnknownMutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells.
Not available
S-EPMC9035570 | biostudies-literature
UnknownPhanto-IDP: compact model for precise intrinsically disordered protein backbone generation and enhanced sampling.
Not available
S-EPMC10783862 | biostudies-literature
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