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ModelsBucher2011_Atorvastatin_Metabolism
This is the model of atorvastatin metabolism in hepaitc cells described in the article: A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes Joachim Bucher , Stephan Riedmaier , Anke Schnabel , Katrin Marcus , G...
2024-09-02 | BIOMD0000000328 | BioModels
UnknownProspective, observational study of pain and analgesic prescribing in medical oncology outpatients with breast, colorectal, lung, or prostate cancer.
Not available
S-EPMC3383175 | biostudies-literature
UnknownRituximab extended schedule or re-treatment trial for low-tumor burden follicular lymphoma: eastern cooperative oncology group protocol e4402.
Not available
S-EPMC4171355 | biostudies-literature
ProteomicsProteomic dissection of human erythropoiesis reveals critical roles of kinases
Human erythropoiesis is exquisitely controlled at multiple levels and its dysregulation leads to anemias and many other diseases. We apply mass spectrometry (MS)-based proteomics to comprehensively investigate the protein and signaling dynamics of this process. Mapping the proteomes and phosphoprote...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD017276 | Pride
Ckit Red blood cells Hematopoietic stem and progenitor cells Differentiation Mapk Phosphoproteomics Epor Human erythropoiesis Proteomics Development Kinase Systems biology Signaling 
ProteomicsThe proteomic landscape of proteotoxic stress in a fibrogenic liver disease
Protein misfolding diseases, including alpha-1 antitrypsin deficiency (AATD), pose significant health challenges, yet their progression at the cellular level remains poorly understood. Here, we employ spatial proteomics by mass spectrometry and machine learning to map the molecular landscape of AATD...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD054440 | Pride
Alpha-1 antitrypsin deficiency Proteotoxic stress Single cell Deep visual proteomics Liver 
ProteomicsDifferential UBE2H-CTLH E2-E3 ubiquitylation modulesregulate erythroid maturation
The developmentof haematopoietic stem cellsinto mature erythrocytes–erythropoiesis –is a controlled process characterized by cellular reorganisation and drastic reshaping of the proteome landscape.Failure of ordered erythropoiesis isassociated with anaemias and haematological maligna...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031992 | Pride
Ube2h Proteomics Dia Ms Gid complex Ubiquitination E2 Ctlh complex E3 
ProteomicsSingle-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Understanding protein distribution patterns across tissue architecture is crucial for deciphering organ function in health and disease. Here, we applied single-cell Deep Visual Proteomics to perform spatially-resolved proteome analysis of individual cells in native tissue. We built a robust framewor...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD062231 | Pride
Deep visual proteomics Single cell proteomics Spatial protein gradients Fibrosis Human liver zonation 
ProteomicsIn alpha-1 antitrypsin deficiency, loss of the mechanistic target of rapamycin complex 1 (mTORC1) causes a lethal hepatic zonation defect
Alpha1-antitrypsin (AAT) mutations lead to the retention of the otherwise secreted protein thereby giving rise to AAT deficiency (AATD). AATD-related liver disease (AATD-LD) arises due to the proteotoxic stress and is the second leading cause of mortality in AATD with no approved pharmacologic treat...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD053427 | Pride
Alpha-1 antitrypsin Dvp Mtorc1 Liver Spatial proteomics 
GenomicsChIP-Seq data from Nup133 ChIP performed on primary male and female mouse derived oligodendrocyte precursor cells
Nup133 is known to play a crucial role in neural cell differentiation. But its downstream targets and the exact mechanisms of its action are largely unknown. Hence, we performed targeted chromatin immunoprecipitation experiments followed by next generation sequencing to identify its genomic targets....
ORGANISM(S): Mus musculus 
2020-09-16 | E-MTAB-7332 | biostudies-arrayexpress
TranscriptomicsNuclear SLIC-CAGE of human cortical neurons from Cornelia de Lange Syndrome patients and control individuals
We used SLIC-CAGE to map transcriptional start sites in cortical neurons from Cornelia de Lange Syndrome (CdLS) patients and control individuals. SLIC-CAGE was performed using nuclear RNA isolated from pre-frontal cortical grey matter. Usage of nuclear RNA allows enrichment of unstable RNAs, such as...
ORGANISM(S): Homo sapiens 
2021-02-27 | E-MTAB-9045 | biostudies-arrayexpress
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