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ProteomicsQuantitative Proteome and Lysine Lactylome of Proteins in the Cortex of Sham and CCI Mouse
Quantitative proteome and lysine lactylome analyses were conducted on proteins extracted from the cortex of sham and controlled cortical impact (CCI) mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD045802 | Pride
Mouse Lactylation Cortex 
ProteomicsIdentification of Tufm-interacting proteins by IP-MS/MS
Tufm-FLAG and its interacting proteins were enriched by immunoprecipitation using Anti-C-Flag Nanobody Agarose Beads. Then, Tufm-FLAG-interacting proteins were identified by mass spectrum.
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD045404 | Pride
Mouse Mitochondria Ip-ms/ms Tufm 
ProteomicsIdentification of N-terminal SUMOylation of mouse cofilin-1 by IP-MS
Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. As a key regulator of actin cytoskeleton dynamics, cofilins (...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038392 | Pride
Mouse Cofilin-1 Ip-ms N-terminal sumoylation 
ProteomicsThe role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Mus Musculus 
2024-03-25 | PXD050941 |
ProteomicsSUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050942 |
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