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ProteomicsQuantitative proteomics of barrier-deficient mouse epidermis in response to environmental humidity
Low environmental humidity aggravates symptoms of inflammatory skin diseases, e.g. of Atopic Dermatitis (AD). Using mice that develop AD-like symptoms, we show that an increase in environmental humidity rapidly rescues their cutaneous inflammation and associated epidermal abnormalities. Quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-14 | PXD007124 | Pride
Mouse Skin Barrier defect Humidity Epidermis Osmoregulation 
ProteomicsMouse liver regeneration quantitative proteomics
The liver is the only organ in mammals, which fully regenerates after injury. To identify novel regulators of liver regeneration, we performed quantitative large-scale proteomics analysis of subcellular fractions from normal versus regenerating mouse liver. Proteins of the ubiquitin-proteasome pathw...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-13 | PXD004108 | Pride
Mouse Liver regeneration Dia Partial hepatectomy Itraq 
ProteomicsImpact of protein search database on metaproteomics outcomes
Unraveling the complex structure and functioning of microbial communities is essential to accurately predict the impact of perturbations and/or environmental changes. From all molecular tools available today to resolve the dynamics of microbial communities, metaproteomics stands out, allowing the es...
ORGANISM(S): Marine Metagenome 
2019-07-12 | PXD014582 |
ProteomicsDiel Protein Regulation of Marine Picoplanktonic Communities Assessed by Metaproteomics
Diel cycle is of enormous biological importance in that it imposes temporal structure on ecosystem productivity. In the world oceans, microorganisms form complex communities that carry out about half of photosynthesis and the bulk of life-sustaining nutrient cycling. Within these natural microbial a...
ORGANISM(S): Marine Metagenome 
2020-03-06 | PXD017373 |
ProteomicsBioID screen for PRSS35 interactors in human primary fibroblasts
We identified the serine protease PRSS35 as a major player in the response to hyperosmotic stress. To gain insight into the mechanisms of action of PRSS35 in human primary fibroblasts, we searched for PRSS35-BirA-HA proximal proteins using BioID interaction screening.
ORGANISM(S): Homo sapiens (Human) 
2023-08-03 | PXD042894 | Pride
Human Q-exactive hf Primary fibroblasts Bioid 
TranscriptomicsFunctional analysis of the cytoprotective transcription factor Nrf2 in skin morphogenesis and disease: Identification of Nrf2 target genes
The Nrf2 transcription factor is a key player in the cellular stress response, which regulates the expression of important antioxidant enzymes and other cytoprotective proteins. We recently generated a novel transgenic mouse model to determine the function of Nrf2 in the skin. These mice revealed in...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35160 | biostudies-arrayexpress
ProteomicsBioID screen for Uhrf2 interactors in AML12 cells
We identified the ubiquitin ligase Uhrf2 as an important regulator of liver regeneration. To gain insight into the mechanisms of action of Uhrf2 in hepatocytes, we searched for Uhrf2 interactors in the AML12 hepatocyte cell line using BioID interaction screening. This resulted in the identification ...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-01 | PXD041732 | Pride
Q-exactive hf Mouse Bioid Aml12 cells 
ProteomicsBioID screen for NRF3 interactors in SCC13 and HaCaT cells
We identified the transcription factor NRF3 as an important tumor-suppressing protein in the skin. To gain insight into the mechanisms of action of NRF3 in keratinocytes, we searched for NRF3 interactors in the SCC13 skin cancer and the immortalized non-tumorigenic HaCaT cell line using BioID intera...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043305 | Pride
Hacat cells Q-exactive hf Nrf3 Scc13 cells Bioid 
TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
We evaluated cutaneous contact hypersensitivity (CHS) in Cnr1-/-/Cnr2-/- animals using the obligate contact allergen 2,4-dinitrofluorobenzene (DNFB), which generates a specific cutaneous T-cell mediated allergic response upon repeated allergen contact. Allergic contact dermatitis affects about 5% of...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-7694 | biostudies-arrayexpress
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