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ProteomicsPeripheral blood proteomic signature of newly diagnosed prostate cancer
Prostate cancer (PCa) is the most common malignant tumour, with high incidence rates and heterogeneity in men around the world. It is becoming an increasing burden on the health care system due to lack of tests for precise detection of disease, risk assessment and response to treatments. We used SWA...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025484 | Pride
Proteomics Clinical onset Swath-ms Biomarkers Prostate cancer 
TranscriptomicsTHOC5 controls 3M-BM-4end-processing of immediate early genes via interaction with CPSF100
Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsic signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that TH...
ORGANISM(S): Mus musculus 
2014-11-03 | E-GEOD-59561 | biostudies-arrayexpress
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
ProteomicsLineage specific metabolic activity in haematopoiesis
Proteins were relatively quantified from the isolated mitochondria undergoing differentiation along two distinct lineages.
ORGANISM(S): Mus musculus (Mouse) 
2017-09-07 | PXD002968 | Pride
Mitochondria Proteomics Hematopoiesis 
ProteomicsNon-Small Cell Lung Cancer patients undergoing radical radiotherapy
Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patients undergoing radiotherapy. Identification of such markers would allow treatment options to be considered for more effective therapy. To enable the identification of appropriate protein biomarke...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD001052 | Pride
Plasma lc-ms lung cancer itraq 
ProteomicsNuclear proteomics in acute myeloid leukemia
The protein differences betweeen primary patient material from AML sufferers and normals was analysed using shotgun proteomics.
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD002799 | Pride
Acute myeloid leukaemia Itraq 
ProteomicsCML proteome analysis, TripleTOF 5600
Using mass spectrometry the proteomes of CML were compared to normal tissue.
ORGANISM(S): Homo sapiens (Human) 
2016-06-03 | PXD001504 | Pride
Cd34+ Itraq Cml 
ProteomicsLeukaemic protein tyrosine kinase comparison in Ba/F3 cells
Taking a series of oncogenic protein tyrosine kinases and constitutively expressing them in Ba/F3 cells, proteomic analysis was utilised in order to identify common protein changes.
ORGANISM(S): Mus musculus (Mouse) 
2016-06-03 | PXD001505 | Pride
Lymphoma Shotgun proteomics Itraq Leukaemia 
ProteomicsCML proteome analysis, LTQ Orbitrap Velos
Using mass spectrometry the proteomes of CML were compared to normal tissue.
ORGANISM(S): Homo sapiens (Human) 
2016-06-03 | PXD001502 | Pride
Cd34+ Shotgun proteomics Itraq Cml 
ProteomicsCML proteome analysis, QSTAR - Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Using mass spectrometry the proteomesof CML were compared to normal tissue.
ORGANISM(S): Homo sapiens (Human) 
2016-06-03 | PXD001503 | Pride
Cd34+ Shotgun proteomics Itraq Cml 
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