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MetabolomicsCharacterization of white tea metabolome: comparison against green and black tea by a nontargeted metabolomics approach
White tea is considered the least processed form of tea and is reported to have a series of potent bioactivities, such as antioxidant, anti-inflammatory, anti-mutagenic, and anti-cancer activities. However, the chemical composition of white tea and the dynamic changes of the metabolites during the m...
2017-03-23 | MTBLS403 | MetaboLights
MetabolomicsIncreased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12 weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To achieve this goal, we compared the brain metabolomes of ipsilateral and contralateral hemispheres from aged male mice u...
2022-10-06 | MTBLS5543 | MetaboLights
MetabolomicsMulti-Omics profiling reveals immunometabolic adaptations underlying disease resilience in indigenous Lueyang Silky Fowl compared to White Leghorns
Sustainable avian production demands genetic strategies beyond vaccines to enhance disease resilience, particularly in indigenous breeds like Lueyang Silky Fowl (LSF), which show superior resistance compared to commercial White Leghorn chickens (WLC) but lack molecular characterization. We hypothesi...
2026-05-27 | MTBLS14590 | MetaboLights
MetabolomicsHarnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights
MetabolomicsMicrobiome and metabolome profiles of severe versus mild influenza A cases: A case-control study

Background: Influenza A virus (IAV) causes a wide spectrum of clinical outcomes, from mild symptoms to life-threatening pneumonia. Recent studies have highlighted the role of the upper respiratory tract (URT) microbiota in modulating immune responses and influencing disease sever...

2025-11-03 | MTBLS13112 | MetaboLights
TranscriptomicsDysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19403 | biostudies-arrayexpress
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (GC- and LC-MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS767 | MetaboLights
ProteomicsDietary administration of a glycosylated form of vitamin D combined with natural triterpenes in late gestating and lactating sows
This study evaluated the effects of dietary supplementation with a glycosylated form of active vitamin D (1,25(OH)₂D₃) combined with natural triterpenes (ursolic and oleanolic acids) in hyper-prolific sows during late gestation and lactation. Twenty-four Landrace × Large White sows were assigned to ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-03-30 | PXD070245 | Pride
Proteomic nanolc-ms/ms 
ProteomicsRat white adipose tissue DIGE-LC-MSMS
White adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mo...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-24 | PXD010902 | Pride
Lc-msms Rat Fasting White adipose tissue 2d-dige 
ProteomicsRed-fleshed apples rich in anthocyanins and white-fleshed apples poor in anthocyanins modulate aorta and heart proteome in hypercholesterolemic rats. The AppleCOR study
New mechanisms-of-action of anthocyanins (ACNs) provided by a red-fleshed apple compared with a white-fleshed apple ACN-poor, and with an ACN-rich extract on the proteome profile of aorta and heart as cardiovascular key tissues were determined. Hypercholesterolemic Wistar rats were separated into th...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-04-04 | PXD018885 | Pride
Rat tissues Proteomics Anthocyanins Phenolic compounds Apple 
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