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ProteomicsIncreased microtubule growth is required for extracellular vesicle mediated HER2 paracrine signaling to promote melanoma cancer cell invasion
The acquisition of cell invasiveness is the key transition from benign melanocyte hyperplasia to aggressive melanoma. Recent work using non-melanoma cancer cells has provided an intriguing new link between the presence of supernumerary centrosomes and increased cell invasion. Moreover, supernumerary...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD032224 | Pride
Paracrine signaling Extracellular vesicles Microtubule 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 1
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049120 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 2
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049124 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 3
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD056432 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
GenomicsMERiC
Data Access Committee EGAC00001000964
EGAC00001000964 | EGA
ProteomicsAPEX2 mediated proximity labeling to investigate the proximal proteome of mitochondria tethered ULK1 in wild type and fip200 knock down cells
The object of this project is to investigate the proximal proteome of ULK1 during mitophagy and the effects of a FIP200 knock down using the APEX2-mediated proximity labeling system. APEX2-ULK1 or APEX2 was fused to 2xFKBP-myc and stably expressed in a cell line stably expressing a truncated FIS1-FR...
ORGANISM(S): Homo sapiens (Human) 
2024-10-12 | PXD047277 | Pride
Fip200 Mitophagy Autophagy Frb-rapalog-fkbp interaction Ulk1 Apex2 Er 
Genomicse4c45bda-86ce-40aa-a3b6-64f2ad0482cc - samples
Whole-exome sequencing was performed from organoids derived from 10 liver cancer biopsies (7 hepatocellular carcinoma and 3 cholangiocarcinoma), corresponding liver and non-tumoral biopsies. For 3 of the organoids, both early and late passage organoids were sequenced. Whole-exome sequencing was perf...
EGAD00001004205 | EGA
GenomicsOrganoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the second cause of cancer-related mortality worldwide. HCC mainly arises in livers with pre-existing underlying diseases including viral hepatitis, alcoholic liver disease and nonalcoholic steatohepatitis. The multikinase in...
EGAS00001003115 | EGA
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