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ProteomicsA Triple Action PROTAC for Wild-Type p53 Cancer Therapy
Multiagent chemotherapy remains a cornerstone of cancer treatment but the side effects of each drug component can heighten toxicity and the pharmacologic challenges in achieving simultaneous cellular delivery can reduce efficacy and promote resistance. To address these limitations, we developed a Tr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD060332 | Pride
Bet proteins Cancer Brd4 Taptac Degradation Mdm2/hdm2 Protac Mdmx/mdm4/hdmx Chimera Therapeutic P53 Stapled peptide 
UnknownThe C-Terminus and Third Cytoplasmic Loop Cooperatively Activate Mouse Melanopsin Phototransduction.
Not available
S-EPMC7376183 | biostudies-literature
TranscriptomicsAlteration of microRNA gene expression by EBV encoded LMP1 oncogene
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10105 | biostudies-arrayexpress
UnknownGut microbiomes of wild great apes fluctuate seasonally in response to diet.
Not available
S-EPMC5934369 | biostudies-literature
UnknownDiscovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.
Not available
S-EPMC2879103 | biostudies-literature
UnknownHydrogen Sulfide Treatment Improves Post-Infarct Remodeling and Long-Term Cardiac Function in CSE Knockout and Wild-Type Mice.
Not available
S-EPMC7352717 | biostudies-literature
UnknownDirect demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
Not available
S-EPMC5555191 | biostudies-literature
UnknownNovel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions.
Not available
S-EPMC3187507 | biostudies-literature
MetabolomicsInsights into Metabolic Changes Caused by the Trichoderma virens-Maize Root Interaction
The interactions of crops with root-colonizing endophytic microorganisms are highly relevant to agriculture, because endophytes can modify plant resistance to pests and increase crop yields. We investigated the interactions between the host plant Zea mays and the endophytic fungus Trichode...
2021-07-08 | MTBLS1964 | MetaboLights
TranscriptomicsThe Polycomb Group Gene EMF2B is required for meristem determinacy and organ specification in rice flowers.
The Polycomb Repressive Complex 2 (PRC2) represses the transcriptional activity of target genes through trimethylation of Lysine 27 of Histone H3. The functions of the plant PRC2 have been chiefly described in Arabidopsis but specific PRC2 functions in other plant species, especially the cereals, ar...
ORGANISM(S): Oryza sativa Japonica Group 
2014-10-31 | E-GEOD-49633 | biostudies-arrayexpress
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