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ProteomicsIntact Protein extraction using Liquid extraction surface analysis (LESA)
Development of a new technique of extraction of intact protein on localized region of tissue section using liquide extraction surface analysis.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-03-14 | PXD001925 | Pride
Lesa Intact proteins extraction 
ProteomicsIntact Protein extraction using Liquid extraction surface analysis (LESA)
Development of a new technique of extraction of intact protein on localized region of tissue section using liquide extraction surface analysis.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-03-14 | PXD002514 | Pride
Quantitative based imaging Rat brain 
ProteomicsA novel treatment for glioblastoma based on Taxol activation of PC1/3-depleted macrophages: evidence from a proteomic and functional study.
Tumor-associated macrophages contribute to tumor pathogenesis and represent an attractive therapeutic target. We report that the proprotein convertase PC1/3 inhibits the TLR4 Myd88-pathway induced in macrophages by the anti-cancer agent Taxol. Thus, PC1/3 knock-down in these cells exacerbates the TL...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-03-19 | PXD004444 | Pride
Taxol Macrophage Intracellular trafficking Shotgun proteomic Tlr4 signaling Calcium Tumors Stat3 Proprotein convertase pc1/3 
ProteomicsDeciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Cellular Extracts
The prohormone convertase 1/3 (PC1/3) is an enzyme playing an important role in the processing of precursor proteins involved in neuroimmune phenotype of neuroendocrine cells. The expression of PC1/3 is not only restricted to neuroendocrine tissues; recent studies reported a role of PC1/3 in Toll-li...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-09 | PXD001984 | Pride
Macrophages Shotgun proteomics 
ProteomicsDeciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Secretomes
The prohormone convertase 1/3 (PC1/3) is an enzyme playing an important role in the processing of precursor proteins involved in neuroimmune phenotype of neuroendocrine cells. The expression of PC1/3 is not only restricted to neuroendocrine tissues; recent studies reported a role of PC1/3 in Toll-li...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-15 | PXD001986 | Pride
Macrophage inhibition 
ProteomicsProteomic analysis of the spatiotemporal based molecular kinetics of acute spinal cord injury identifies a time- and segment-specific window for effective tissue repair - IgG identification
Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular progression of injury sequel due from the lesion site, still the exact underlyi...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-06-08 | PXD004247 | Pride
1d gel Mass spectrometry Igg Spinal cord injury 
ProteomicsEvaluation of Non-Supervised MALDI Mass Spectrometry Imaging Combined to MicroProteomics for Glioma Grade III Classification
An integrated diagnosis using molecular features is recommended in the updated World Health Organization (WHO) classification. Our aim was to explore the role of MALDI-Mass spectrometry imaging (MSI) coupled to microproteomics in order to classify anaplastic glioma by integration of clinical data.
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD004437 | Pride
Matrix-assisted laser desorption/ionization mass spectrometry imaging Anaplastic glioma Microproteomics 
ProteomicsFallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis.
The main goal of this study is to explore the proteomic expression in prophylactic salpingooophorectomy specimens, obtained from highly selected cohort of patients at risk of developing a high-grade serous ovarian carcinoma (HGSOC), because of a hereditary (BRCA 1 or 2 mutation) or a documented fami...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD020024 | Pride
Pre-neoplastic lesions Oavrian cancer Spatially resolved proteomics Ihc Proteomics 
ProteomicsProteomic analysis of the spatiotemporal based molecular kinetics of acute spinal cord injury identifies a time- and segment-specific window for effective tissue repair.
Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular progression of injury sequel due from the lesion site, still the exact underlyi...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-06-08 | PXD003375 | Pride
Spinal cord lesion Proteomics Mass spectrometry imaging Microglial cells 
ProteomicsMechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine
The skin plays a crucial role in host defences against microbial attack and the innate cells must provide the immune system with sufficient information to organize these defences. This unique feature makes the skin a promising site for vaccine administration. Although cellular innate immune events d...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD017313 | Pride
Skin  biomarkers  mass spectrometry  intradermal vaccination  innate immunity 
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