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GenomicsEpigenetic profiling of cells following WM-1119 treatment
Epigenetic profiling of cells following WM-1119 treatment
PRJNA659933 | ENA
GenomicsTranscriptional profiling of cells following WM-1119 treatment
Transcriptional profiling of cells following WM-1119 treatment
PRJNA659647 | ENA
GenomicsEpigenetic profiling of cells following WM-1119 treatment
ChIP-seq analysis of MOLM-13 human leukemia cells treated with DMSO or WM-1119 for 4 days
ORGANISM(S): Homo sapiens 
2021-10-20 | GSE157042 | GEO
TranscriptomicsTranscriptional profiling of cells following WM-1119 treatment
RNA-seq analysis of MOLM-13 human leukemia cells or mouse ER-Hoxa9 treated with DMSO or WM-1119 for 4 days
ORGANISM(S): Homo sapiens Mus musculus 
2021-10-20 | GSE156947 | GEO
GenomicsRNA-seq profiling of a mouse B cell lymphoma cell line treated with the KAT6A/B inhibitor WM-1119
RNA-seq profiling of a mouse B cell lymphoma cell line treated with the KAT6A/B inhibitor WM-1119
PRJNA473345 | ENA
TranscriptomicsRNA-seq profiling of a mouse B cell lymphoma cell line treated with the KAT6A/B inhibitor WM-1119
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function. The MYST family of KATs (KAT5-8) includes the oncogenes KAT6A (MOZ) and KAT6B (MORF/QKF). KAT6A has essential roles in normal hematopoietic stem cells and is the target of recurrent chro...
ORGANISM(S): Mus musculus 
2018-08-03 | GSE114962 | GEO
UnknownThe small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Not available
S-EPMC11462755 | biostudies-literature
ProteomicsHierarchical small molecule inhibition of MYST acetyltransferases
MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074488 | Pride
Histone acetylation Lysine acetyltransferases Wm-1119 Wm-3835 Drug-like myst inhibitors Chemoproteomics Myst Foxk2 Pf-9363 Wm-8014 
TranscriptomicsTargeting cell cycle and apoptosis to overcome chemoresistance in AML
A genome-wide CRISPR knockout screen investigating resistance to doxorubicin and cytarabine (Dox/AraC) in human AML cell lines identified gene knockout of cyclin dependent kinase inhibitor 2A (CDKN2A) as contributing to resistance. To investigate the therapeutic potential of upregulating CDKN2A expr...
ORGANISM(S): Homo sapiens 
2022-11-22 | GSE205802 | GEO
TranscriptomicsRNA-seq profiling of mouse embyonic fibroblasts treated with the Myst inhibitor WM-8014
Acetylation of histones by lysine acetyltransferases (KATs) is essential for transcriptional regulation of gene expression. The MYST family of KATs (KAT5-8) includes the oncogenes KAT6A (MOZ) and KAT6B (MORF/QKF). KAT6A has key roles in promoting cell proliferation through transcriptional activation...
ORGANISM(S): Mus musculus 
2018-08-03 | GSE108243 | GEO
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