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GenomicsEffect of WM-3835 treatment and HBO1 S50/53A mutation on gene expression of OMM2.3 cells
Effect of WM-3835 treatment and HBO1 S50/53A mutation on gene expression of OMM2.3 cells
PRJNA1273976 | ENA
TranscriptomicsEffect of WM-3835 treatment and HBO1 S50/53A mutation on gene expression of OMM2.3 cells
To investigate the changes in gene expression profiles in OMM2.3 cells induced by WM-3835, we treated OMM2.3 cells with 20μM WM-3835 for 48 hours; To investigate the changes in gene expression profiles in OMM2.3 cells after HBO1 S50/53A mutaion, we established Flag_HBO1 and Flag_HBO1S50/53A overexpr...
ORGANISM(S): Homo sapiens 
2026-09-17 | GSE299365 | GEO
UnknownA first-in-class HBO1 inhibitor WM-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo.
Not available
S-EPMC9884225 | biostudies-literature
ProteomicsHierarchical small molecule inhibition of MYST acetyltransferases
MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074488 | Pride
Histone acetylation Lysine acetyltransferases Wm-1119 Wm-3835 Drug-like myst inhibitors Chemoproteomics Myst Foxk2 Pf-9363 Wm-8014 
UnknownKAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway.
Not available
S-EPMC11970613 | biostudies-literature
UnknownThe histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma.
Not available
S-EPMC7978299 | biostudies-literature
GenomicsTargeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma [ChIP-Seq]
Glioblastoma multiforme (GBM), the most lethal type of primary brain tumor, exhibits profound metabolic plasticity driven by glioma stem cells (GSCs), which sustain therapeutic resistance and tumor recurrence. Here, we elucidate a novel epigenetic-metabolic axis mediated by the histone acetyltransfe...
ORGANISM(S): Homo sapiens 
2026-09-16 | GSE328308 | GEO
TranscriptomicsTargeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma [RNA-Seq]
Glioblastoma multiforme (GBM), the most lethal type of primary brain tumor, exhibits profound metabolic plasticity driven by glioma stem cells (GSCs), which sustain therapeutic resistance and tumor recurrence. Here, we elucidate a novel epigenetic-metabolic axis mediated by the histone acetyltransfe...
ORGANISM(S): Homo sapiens 
2026-09-16 | GSE328130 | GEO
ProteomicsHierarchical small molecule inhibition of MYST acetyltransferases
MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-04-23 | MSV000097704 | MassIVE
UnknownHierarchical small molecule inhibition of MYST acetyltransferases.
Not available
S-EPMC12478385 | biostudies-literature
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