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MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
TranscriptomicsMicroarray (one-color) gene expression analysis of Euglena gracilis subjected to altered acceleration during parabolic flight
Euglena gracilis is a unicellular freshwater flagellate, which uses the gravitational vector for orientation in the water column in the dark. This allows the cell to reach areas in the water column for reproduction and growth. How exactly the gravitational vector is perceived, and which intracellula...
ORGANISM(S): Euglena gracilis 
2019-07-09 | E-MTAB-8064 | biostudies-arrayexpress
UnknownAltered PLP1 splicing causes hypomyelination of early myelinating structures.
Not available
S-EPMC4479525 | biostudies-literature
TranscriptomicsStem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells
Gastric cancer is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with H. pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-42937 | biostudies-arrayexpress
GenomicsGenome-wide distribution of 5-formylcytosine in ES cells is associated with transcription and depends on TDG
Methylation of cytosine in DNA (5mC) is an important epigenetic mark that is involved in the regulation of genome function. During early embryonic development in mammals, the DNA methylation landscape is dynamically reprogrammed in part through active demethylation. Recent advances have identified k...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40148 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 7G8 cell bank parasites
The parasite Plasmodium falciparum is responsible for severe malaria, which remains a major cause of death, particularly in sub-Saharan Africa. The reference strain NF54 (or its subclone 3D7) is commonly used for controlled human malaria infection (CHMI), but recently strains with a different geogra...
ORGANISM(S): Plasmodium falciparum 7G8 
2022-09-22 | E-MTAB-12157 | biostudies-arrayexpress
UnknownEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.
Not available
S-EPMC11275670 | biostudies-literature
GenomicOncoArray: Prostate Cancer

Original description of the study: From ELLIPSE (linked to the PRACTICAL consortium), we contributed ~78,000 SNPs to the OncoArray. A large fraction of the content was derived from the GWAS meta-analyses in European ancestry populations (overall and aggressive disease; ~27K SNPs). We also ...

phs001391 | dbGaP
UnknownEnhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.
Not available
S-EPMC8917986 | biostudies-literature
UnknownAn original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.
Not available
S-EPMC4478717 | biostudies-literature
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