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ProteomicsRab30 regulates lipid homeostasis in the hepatocyte during fasting
In order to facilitate inter-tissue communication and exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Rab30, a putative Golgi-localized Rab GTPase, is induced in th...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD050376 | Pride
Rab gtpases  liver  ppara  lipid metabolism  fasting 
ProteomicsRab30 regulates lipid homeostasis in the hepatocyte during fasting
In order to facilitate inter-tissue communication and exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Rab30, a putative Golgi-localized Rab GTPase, is induced in th...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-12 | PXD044528 | Pride
Lipoprotein Lipid metabolism Triglycerides Beta oxidation Vesicle transport Ppara Golgi apparatus Small gtpase 
ProteomicsEtomoxir as a Promiscuous Chemoproteomic Probe.
Primary hepatocytes from WT or Pex5KO mouse livers were treated with 100uM clickable etomoxir analogues and the proteins bound to etomoxir were pulled down and identified. The small molecule inhibitor etomoxir has been used for many years as a specific inhibitor of Cpt1 but these data show that etom...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD045866 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsEtomoxir: A Promiscuous Fatty Acid Mimetic Chemoproteomic Probe
Etomoxir has been used for decades as a popular small molecule inhibitor of Carnitine Palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid b-oxidation. To test the specificity of etomoxir, we generated click chemistry enabled reagents to label etomoxir binding proteins in situ. Etomoxir b...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD051969 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsRequirement of hepatic pyruvate carboxylase during fasting, high fat and ketogenic diet
Pyruvate has two major fates upon entry into mitochondria, the oxidative decarboxylation to acetyl-CoA or the biotin-dependent carboxylation to oxaloacetate via pyruvate carboxylase (Pcx). Here we have generated mice with a liver specific knockout of pyruvate carboxylase (PcxL-/-) to understand the...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-31 | PXD032028 | Pride
Ketogenesis Acetyl-proteomics Pyruvate carboxylase Mitochondria 
UnknownActivating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress.
Not available
S-EPMC12059330 | biostudies-literature
UnknownLoss of Fatty Acid Oxidation by Neural Stem and Progenitor Cells Increases Proliferation but Does Not Improve Long-Term Neurogenesis After Mild Traumatic Brain Injury.
Not available
S-EPMC12818800 | biostudies-literature
UnknownDysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate.
Not available
S-EPMC12827289 | biostudies-literature
ProteomicsDysregulated Hippocampal Fatty Acid Metabolism Following Intermittent Hypoxemia-induced Neonatal Brain Injury is Rescued by Treatment with Acetate – Normoxia vs Intermittent Hypoxia – Sex Difference Analysis
The brain is a lipid-rich organ that experiences rapid growth and development after birth in a period hallmarked by extensive lipid synthesis. We still lack a fundamental understanding of lipid metabolism during this critical time of brain development and how these dynamics occur in infants born ext...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-20 | PXD070491 | Pride
Hippocampus Tmt Orbitrap Mouse Neonatal brain injury Intermittent hypoxia 
UnknownCirculating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer.
Not available
S-EPMC7403524 | biostudies-literature
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