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TranscriptomicsshRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control
TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic. We now show that TGFβ-dependent cell migration, invasion and metastasis are empowered by mutant-p...
ORGANISM(S): Homo sapiens 
2009-04-11 | E-GEOD-14491 | biostudies-arrayexpress
UnknownAssociation of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.
Not available
S-EPMC5664310 | biostudies-literature
TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that bi-allelic inactivation of Lkb1 and Pten in the mouse lung led to SCC that recapitulated the histology, gene expression and microenvironment found in human disease. Lkb1/Pten-null ...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54351 | biostudies-arrayexpress
ProteomicsRepurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
The myeloma bone marrow microenvironment drives proliferation of malignant plasma cells and promotes resistance to therapy. Interleukin-6 (IL-6) and downstream JAK/STAT signaling are thought to be central components of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006581 | Pride
Lc-msms Lfq Myeloma Bone marrow microenvironment Tofacitinib Human 
ProteomicsRegulated local synthesis of ribosomal proteins maintains ribosome function in axons
Ribosome assembly occurs mainly in the nucleolus yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and functional interaction between locally synthesized RPs and ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-09 | PXD015574 | Pride
Ribosomes Sucrose density gradient fractionation Axon 
ProteomicsSILAC-labeled proteins in ribosome samples
we developed a novel method combining axon-pSILAC17 with axonal ribosome purification. In this method, we first labeled newly synthesized proteins with heavy amino acids (AAs) in somaless axons cultured in a Boyden chamber. Approximately 2000 eyes were cultured for each experiment to obtain sufficie...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-09 | PXD011032 | Pride
Xenopus laevis Axon Ribosome Silac 
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
GenomicsA Multiethnic Genome wide Scan of Prostate Cancer

Multiple GWA studies of prostate cancer conducted in European White populations are ongoing. These studies will continue to have a dramatic impact on our understanding of the contribution of common genetic variation on inter-individual susceptibility to this common cancer. Important questions tha...

phs000306.v3.p1 | EGA
GenomicsMulti-regional tumour biopsies of a RET fusion patient
Identifying modes of resistance to a new experimental drug for a patient resistant to other therapies
EGAS00001004023 | EGA
Genomics200PT.bam - samples
200PT : WG Aligned Sequence (bam)/ Aligned WG sequence data in this dataset are from CPCGene Tumour/Normal Pairs used in the 200PT Study
EGAD00001004061 | EGA
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